Induced pluripotent stem cells (also known as iPS cells or iPSCs) are a type of pluripotent stem cell that can be generated directly from a somatic cell. The iPSC technology was pioneered by Shinya Yamanaka’s lab in Kyoto, Japan, who showed in 2006 that the introduction of four specific genes (named Myc, Oct3/4, Sox2 and Klf4) encoding transcription factors could convert somatic cells into pluripotent stem cells. He was awarded the 2012 Nobel Prize along with Sir John Gurdon "for the discovery that mature cells can be reprogrammed to become pluripotent."
Pluripotent stem cells hold promise in the field of regenerative medicine. Because they can propagate indefinitely, as well as give rise to every other cell type in the body (such as neurons, heart, pancreatic, and liver cells), they represent a single source of cells that could be used to replace those lost to damage or disease.
Components of the Book:
- Chapter 1
An isogenic neurovascular unit model comprised of human induced pluripotent stem cell-derived brain microvascular endothelial cells, pericytes, astrocytes, and neurons
- Chapter 2
Induced Pluripotent Stem Cell Lines Derived from Equine Fibroblasts
- Chapter 3
Generation of pig induced pluripotent stem cells using an extended pluripotent stem cell culture system
- Chapter 4
Anti-addiction Drug Ibogaine Prolongs the Action Potential in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes
- Chapter 5
Generation of hematopoietic stem/progenitor cells with sickle cell mutation from induced pluripotent stem cell in serum-free system
- Chapter 6
Development of a model of ischemic heart disease using cardiomyocytes differentiated from human induced pluripotent stem cells
- Chapter 7
Efficient differentiation and purification of human induced pluripotent stem cell-derived endothelial progenitor cells and expansion with the use of inhibitors of ROCK, TGF-β, and GSK3β
- Chapter 8
Lens epithelial cells-induced pluripotent stem cells as a model to study epithelial-mesenchymal transition during posterior capsular opacification
- Chapter 9
Human Induced Pluripotent Stem Cell Models of Neurodegenerative Disorders for Studying the Biomedical Implications of Autophagy
- Chapter 10
Generation of induced pluripotent stem cells-derived hepatocyte-like cells for ex vivo gene therapy of primary hyperoxaluria type 1
- Chapter 11
Novel Adult-Onset Systolic Cardiomyopathy Due to MYH7 E848G Mutation in Patient-Derived Induced Pluripotent Stem Cells
- Chapter 12
Kinetic modeling of human induced pluripotent stem cell expansion in suspension culture
- Chapter 13
Telomere dynamics and hematopoietic differentiation of human DKC1-mutant induced pluripotent stem cells
Readership:
Students, academics, teachers and other people attending or interested in Induced Pluripotent Stem Cell
Roy Joseph, Department of Optometry and Vision Science, University of Alabama at Birmingham,USA
Yu Wang, State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
Liang Zhong, CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
Sean P. Palecek, Department of Chemical and Biological Engineering, University of Wisconsin, Madison, USA
Kristina Nagy, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
Siamak Agha-Mohammadi, Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, USA
and more...