Biography

Dr. Corey R. Hopkins

Department of Pharmacology and Chemistry

Vanderbilt Center for Neuroscience Drug Discovery

Vanderbilt University Medical Center, USA

Research Assistant Professor


Email: corey.r.hopkins@vanderbilt.edu


Qualifications

1995-2001 Ph.D., University of Pittsburgh

1987-1992 B.S., Indiana University, Chemistry


Publications (selected)

  1. “Synthesis and SAR of analogs of the M1 allosteric agonist TBPB. Part III. Abolishing high affinity M1 allosteric binding leads to pan-mAChR antagonism”, Sheffler, D. J.; Sevel, C.; Le, U.; Lovell, K. M.; Tarr, J. C.; Cho, H. P.; Digby, G. J.; Niswender, C. M.; Conn, P. J.; Hopkins, C. R.; Wood, M. R.; Lindsley, C. W.* Bioorg. Med. Chem. Lett. 2012, Submitted.
  2. “Identification and Characterization of a Compound that Protects Cardiac Tissue From Human Ether-à-go-go-Related Gene (hERG)-Related, Drug-Induced Arrhythmias”, Potet, F.; Lorinc, A. N.; Chaigne, S.; Hopkins, C. R.; Venkataraman, R.; Stepanovic, S. Z.; Lewis, L. M.; Days, E.; Sidorov, V. Y.; Engers, D. W.; Zou, B.; Afshartous, D.; Balser, J. R.; Li, M.; Baudenbacher, F. J.; Lindsley, C. W.; Weaver, C. D.; Kuperschmidt, S.* J. Biol. Chem. 2012, Submitted.
  3. “The hereditary spastic paraplegia proteins spartin and maspardin interact in a pathway that regulates BMP signaling”, Clowes, V. E.; Edwards, T. L.; Angus, K. L.; Warren, J.; Harbour, M. E.; Hopkins, C. R.; Hong, C. C.; Blackstone, C.; Hanna, M.; Reid, E.* Human Molecular Genetics 2012, Submitted.
  4. “DMH1, a novel BMP small molecule inhibitor, increases cardiomyocyte progenitors and promotes cardiac differentiation in mouse embryonic stem cells”, Ao, A.*; Hao, J.; Hopkins, C. R.; Hong, C. C. PLoS ONE 2012, 7, e41627. DOI: 10.1371/journal.pone.0041627. PMID: 22848549.
  5. “Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective Kv7.1 (KCNQ1) potassium channel activator”, Mattmann, M. E.; Yu, H.; Lin, Z.; Xu, K.; Huang, X.; Long, S.; Wu, M.; McManus, O. B.; Engers, D. W.; Le, U. M.; Li, M.*; Lindsley, C. W.; Hopkins, C. R.* Bioorg. Med. Chem. Lett. 2012, Accepted. DOI: 10.1016/j.bmcl.2012.07.060.
  6. “Discovery of a Series of 2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)acetamides as Novel Molecular Switches that Modulate Modes of Kv7.2 (KCNQ2) Channel Pharmacology: Identification of (S)-2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide (ML252) as a Potent, Brain Penetrant Kv7.2 Channel Inhibitor”, Cheung, Y.-Y.; Yu, H.; Xu, K.; Zou, B.; Wu, M.; McManus, O. B.; Li, M.*; Lindsley, C. W.; Hopkins, C. R.* J. Med. Chem. 2012, Just Accepted, online 07/13/2012. DOI: 10.1021/jm300700v. PMID: 22793372.
  7. “Iterative experimental and virtual high-throughput screening identifies metabotropic glutamate receptor subtype 4 positive allosteric modulators”, Mueller, R.; Dawson, E. S.; Niswender, C. M.; Butkiewicz, M.; Hopkins, C. R.; Weaver, C. D.; Lindsley, C. W.; Conn, P. J.; Meiler, J.* J. Mol. Model. 2012, Online First, 17 May 2012, DOI: 10.1007/s00894-012-1441-0. PMID: 22592386.
  8. “Discovery of N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)isonicatinamide, ML293, as a novel, selective and brain penetrant positive allosteric modulator of the muscarinic 4 (M4) receptor”, Salovich, J. M.; Vinson, P. N.; Sheffler, D. J.; Lamsal, A.; Utley, T. J.; Blobaum, A. L.; Bridges, T. M.; Le, U.; Jones, C. K.; Wood, M. R.; Daniels, J. S.; Conn, P. J.; Niswender, C. M.; Lindsley, C. W.; Hopkins, C. R.* Bioorg. Med. Chem. Lett. 2012, 22(15), 5084-5088. DOI: 10.1016/j.bmcl.2012.05.109. PMID: 22738637.
  9. “DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: Comparison of PAX6 and SOX1 expression during neural induction”, Neely, M. D.*; Litt, M. J.; Tidball, A. M.; Li, G. G.; Aboud, A. A.; Hopkins, C. R.; Chamberlin, R.; Hong, C. C.; Ess, K. C.; Bowman, A. B. ACS Chem. Neursci. 2012, 3, 482-491. DOI: 10.1021/cn300029t. PMID: 22860217.
  10. “The mGlu4 positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine A2A antagonist in preclinical rodent models of Parkinson’s disease”, Jones, C. K.; Bubser, M.; Thompson, A. D.; Dickerson, J. W.; Turle-Lorenzo, N.; Amalric, M.; Blobaum, A. L.; Bridges, T. M.; Morrison, R. D.; Jadhav, S.; Engers, D. W.; Italiano, K.; Bode, J.; Daniels, J. S.; Lindsley, C. W.; Hopkins, C. R.; Conn, J. P.; Niswender, C. M.* J. Pharmacol. Exper. Ther. 2012, 340, 404-421. DOI: 10.1124/jpet.111.187443. PMID: 22088953. • For a highlight, see: SciBx 2011, 4(46), doi: 10.1038/scibx.2011.1301. This week in therapeutics, Neurology. • Most-Read articles J. Pharmacol. Exper. Ther. for month of November 2011.
  11. “Discovery, characterization and structure-activity relationships of an inhibitor of inward rectifying potassium (Kir) channels with preference for Kir2.3, Kir3.X and Kir7.1”, Raphemot, R.*; Lonergan, D. L.; Nguyen, T. T.; Utley, T.; Lewis, L. M.; Kadakia, R.; Weaver, C. D.; Gogliotti, R.; Hopkins, C. R.; Lindsley, C.; Denton, J. S. Frontiers in Pharmacology: Pharmacology of Ion Channels and Channelopathis 2011, 2, Article 75. DOI: 10.3389/fphar.2011.00075.
  12. “The Discovery and Characterization of ML218: A novel, centrally active T-Type Calcium Channel Inhibitor with Robust Effects in STN Neurons and in a Rodent Model of Parkinson’s Disease”, Zixiu, X.; Thompson, A. D.; Brogan, J. T.; Schulte, M. L.; Melancon, B. J.; Mi, D.; Lewis, L. M.; Zou, B.; Yang, L.; Morrison, R.; Santomango, T.; Byers, F.; Brewer, K.; Aldrich, J. S.; Yu, H.; Dawson, E. S.; Li, M.; McManus, O.; Jones, C. K.; Daniels, J. S.; Hopkins, C. R.; Xie, X. S.; Conn, P. J.; Weaver, C. D.; Lindsley, C. W.* ACS Chem. Neurosci. 2011, 2, 730-742. DOI: 10.1021/cn200085z. PMID: 22368764.
  13. “Discovery, Synthesis, SAR Development of a Series of N-4-(2,5-dioxopyrrolidin-1-yl)-phenylpicolinamides: Characterization of VU0400195 (ML182) as a Positive Allosteric Modulator of Metabotropic Glutamate Receptor 4 (mGlu4) with Oral Efficacy in an anti-Parkinsonian Animal Model”, Jones, C. K.; Engers, D. W.; Thompson, A. D.; Field, J. R.; Blobaum, A. L.; Lindsley, S. R.; Zhou, Y.; Gogliotti, R. D.; Jadhav, S.; Zamorano, R.; Bogenpohl, J.; Smith, Y.; Daniels, J. S.; Morrison, R.; Weaver, C. D.; Conn, P. J.; Lindsley, C. W.; Niswender, C. M.*; Hopkins, C. R.* J. Med. Chem. 2011, 54, 7639-7647. DOI: 10.1021/jm200956q. PMID: 21966889.
  14. “Synthesis and SAR of a novel metabotropic glutamate receptor 4 (mGlu4) antagonist: Unexpected ‘molecular switch’ from a closely related mGlu4 positive allosteric modulator”, Utley, T.; Haddenham, D.; Salovich, J. M.; Zamorano, R.; Vinson, P. N.; Lindsley, C. W.; Hopkins, C. R.*; Niswender, C. M.* Bioorg. Med. Chem. Lett. 2011, 21, 6955-6959. DOI: 10.1016/j.bmcl.2011.09.131. PMID: 22030026.
  15. “Identification of ML204 – a novel, potent antagonist that selectively modulates TRPC4 currents”, Miller, M.; Shi, J.; Zhu, Y.; Kustov, M.; Tian, J.-b.; Stevens, A.; Wu, M.; Long, S.; Yang, P.; Zholos, A. V.; Salovich, J. M.; Weaver, C. D.; Hopkins, C.*; Lindsley, C. W.; McManus, O.; Li, M.*; Zhu, M. X. J. Biol. Chem. 2011, 286, 33436-33446. DOI: 10.1074/jbc.M111.274167. PMID: 21795696.
  16. “Application of Small Organic Molecules Reveals Cooperative TGFβ and BMP Regulation of Mesothelial Cell Behaviors”, Cross, E. E.; Thomason, R. T.; Martinez, M.; Hopkins, C. R.; Hong, C. C.; Bader, D.* ACS Chem. Biol. 2011, 6, 952-961. DOI: 10.1021/cb200205z. PMID: 21740033.
  17. “Discovery, Synthesis, and Structure–Activity Relationship of a Series of N-Aryl-bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a Novel KCNQ2 and KCNQ4 Potassium Channel Opener”, Yu, H.; Wu, M.; Townsend, S. D.; Zou, B.; Long, S.; Daniels, J. S.; McManus, O. B.; Li, M.*; Lindsley, C. W.; Hopkins, C. R.* ACS Chem. Neurosci. 2011, 572-577. DOI: 10.1021/cn200065b. PMID: 22125664.
  18. “Selective inhibition of the Kir2 family of inward rectifier potassium channels by a small molecule probe: the discovery, SAR and pharmacological characterization of ML133”, Wang, H.-R.; Wu, M.; Yu, H.; Long, S.; Stevens, A.; Engers, D. W.; Sackin, H.; Daniels, J. S.; Dawson, E. S.; Hopkins, C. R.; Lindsley, C. W.*; Li, M.*; McManus, O. B. ACS Chem. Biol. 2011, 6, 845-856. DOI: 10.1021/cb200146a. PMID: 21615117.
  19. “Solution-Phase Parallel Synthesis and SAR of Homopiperazinyl Analogs as Positive Allosteric Modulators of mGlu4”, Cheung, Y.-Y.; Zamorano, R.; Blobaum, A. L.; Weaver, C. D.; Conn, P. J.; Lindsley, C. W.; Niswender, C. M.; Hopkins, C. R.* ACS Comb. Sci. 2011, 13, 159-165. DOI: 10.1021/co1000508. PMID: 21338051.
  20. “Discovery, Synthesis, and Structure–Activity Relationship Development of a Series of N-(4-Acetamido)phenylpicolinamides as Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4 (mGlu4) with CNS Exposure in Rats”, Engers, D. W.; Field, J. R.; Le, U.; Zhou, Y.; Bolinger, J. D.; Zamorano, Z.; Blobaum, A. L.; Jones, C. K.; Jadhav, S.; Weaver, C. D.; Conn, P. J.; Lindsley, C. W.; Niswender, C. M.*; Hopkins, C. R.* J. Med. Chem. 2011, 54, 1106-1110. DOI: 10.1021/jm101271s. PMID: 21247167.


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