Prof. Masashi Kato

Chubu University, Japan

Email: katomasa@isc.chubu.ac.jp

Qualifications

1995 Ph.D., Nagoya University, Japan

1988 M.D., Fukui Medical School, Japan

Publications (Selected)

1. Kimpfler S, Ring S, Falk C, Osen W, Kato M, Mahnke K, Schadendorf D, Umansky V: Skin Melanoma Development in Ret Transgenic Mice Despite the Depletion of CD25+FoxP3+ Regulatory T-Cells in Lymphoid Organs. J Immunol 183(10):6330-7, 2009.
2. Hossain K, Kawamoto Y, Hamada M, Akhand A, Yanagishita T, Hoque Md. A, Tsuboi H, Kato M, Nakashima I: 1,4-butanediyl-bismethanethiosulfonate (BMTS) induces reactive oxygen species-mediated apoptotic signals independent of stress-activated MAPK cascade in Jurkat cells. J Cell Biochem 108(5):1059-65, 2009.
3. Kumasaka YM, Yajima I, Hossain K, Iida M, Tsuzuki T, Ohno T, Takahashi M, Yanagisawa M, Kato M: A Novel Mouse Model for de novo melanoma. Cancer Res 70(1):24-9, 2010.
4. Ohshima Y, Yajima I, Kumasaka YM, Yanagishita T, Watanabe D, Takahashi M, Inoue Y, Ihn H, Matsumoto Y, Kato M: Increased CD109 expression levels in human malignant melanoma, J Dermatol Sci 57(2):140-2, 2010.
5. Helfrich I, Scheffrahn I, Bartling S, Weis J, von Felbert V, Middleton M, Kato M, Ergün S and Schadendorf D: Resistance to anti-angiogenic therapy is directed by vascular phenotype, vessel stabilization and maturation in malignant melanoma. J Exp Med 207(3):491-503, 2010.
6. Kato M, Takeda K, Hossain K, Thang D. Nguyen, Kaneko Y, Kumasaka M, Yamanoshita O, Uemura N, Takahashi M, Ohgami N, Kawamoto Y. A redox-linked novel pathway for arsenic-mediated RET tyrosine kinase activation. J Cell Biochem (in press), 2010.
7. Kato M, Ohnuma S, Kato Y, Thang D. Nguyen, Yajima I, Hoque Z. Mohammad, Shekhar U. Hossain. Toxic Elements in Well Water from Malaysia. Toxicol Environ Chem, (in press), 2010.
8. Ohshima Y, Yajima I, Takeda K, Iida M, Kumasaka M, Matsumoto Y, Kato M. c-RET molecule in malignant melanoma from oncogenic RET-carrying transgenic mice and human cell lines. PLoS ONE 5(4):e10279, 2010.
9. Eyles J, Puaux A, Wang J, Toh B, Prakash C, Hong M, Zheng L, Ong LC, Jin Y, Kato M, Blondel AP, Chow P, Yang H, Abastado J-P. Tumor cells disseminate early but immunosurveillance limits metastatic outgrowth in a mouse model of melanoma. J Clin Invest 120(6), 2030-9, 2010.
10. Ohgami N, Ida M, Shimotake T, Sakashita N, Sone M, Nakashima T, Tabuchi K, Hoshino T, Shimada A, Tsuzuki T, Yamamoto M, Sobue G, Jijiwa M, Asai N, Hara A, Takahashi M, Kato M: c-Ret–mediated hearing loss in mice with Hirschsprung disease. Proc Natl Acad Sci USA 107(29):13051-6, 2010.
11. Khoury DE, Destouches D, Lengagne R, Krust B, Hamma-Kourbali Y, Garcette M, Niro S, Kato M, Briand J-P, Courty J, Hovanessian AG, Prévost-Blondel A. Targeting Surface Nucleolin with a Multivalent Pseudopeptide Delays Development of Spontaneous Melanoma in RET Transgenic Mice. BMC Cancer 10:325, 2010.
12. Ohgami N, Kondo T, Kato M. Effects of light smoking on extra-high-frequency auditory thresholds in young adults. Toxicol Ind Health 27:143-147, 2011.
13. Kato M, Kumasaka MY, Takeda K, Hossain K, Iida M, Goto Y, Ohgami N. L-cysteine as a regulator for arsenic-mediated cancer-promoting and anti-cancer effects. Toxcol In Vitro, 25:623–629, 2011.
14. Kawakami T, Kumasaka M, Kato M, Mizoguchi M, Soma Y. BMP-4 down-regulates the expression of Ret in murine melanocyte precursors. J Dermatol Sci 63(1):66-9, 2011.
15. Taguchi N, Uemura N, Goto Y, Sakura M, Hara K, Niwa M, Iida M, Yanagishita T, Watanabe D, Kato M. Antioxidative effects of cherry leaves extract on tert-butyl hydroperoxide-mediated cytotoxicity through regulation of thioredoxin-2 protein expression level. J Toxicol Environ Health A 15;74(18):1240-7, 2011.
16. Ohgami N, Ida-Etoh M, Sakashita N, Sone M, Nakashima N, Tabuchi K, Hoshino T, Shimada A, Tsuzuki T, Yamamoto M, Sobue G, Jijiwa M, Asai N, Hara A, Takahashi M, Kato M. Partial impairment of c-Ret at tyrosine 1062 accelerates age-related hearing loss in mice. Neurobiol Aging, in press, 2011.
17. Nakashima I, Kawamoto Y, Takeda K, Kato M. Control of Genetically Designed Protein Tyrosine Kinase Activities by Environment-Linked Redox Reactions. Enzyme Res 10: 896567, 2011 [Review].
18. Furukawa A, Kawamoto Y, Chiba Y, Takei S, Hasegawa-Ishii S, Kawamura N, Yoshikawa K, Hosokawa M, Oikawa S, Kato M, Shimada A. Proteomic identification of hippocampal proteins vulnerable to oxidative stress in excitotoxin-induced acute neuronal injury. Neurobiol Dis 43(3):706-14, 2011.
19. Lengagne R, Pommier A, Caron J, Douguet L, Garcette M, Kato M, Avril M-F, Abastado J-P, Bercovici N, Lucas B and Prevost-Blondel A. T Cells Contribute to Tumor Progression by Favoring Pro-Tumoral Properties of Intra-Tumoral Myeloid Cells in a Mouse Model for Spontaneous Melanoma. PLoS ONE, 6(5):e20235, 2011.
20. Kato M, Iida M, Goto Y, Kondo T, Yajima I. Sunlight exposure-mediated DNA damage in young adults. Cancer Epidemiol Biomaker Prevent, 20(8):1622-8, 2011.
21. Ida-Eto M, Ohgami N, Iida M, Takaiwa K, Kimitsuki T, Sone M, Nakashima T, Tsuzuki T, Komune S, Yanagisawa M, Kato M. Requirement of endothelin receptor B expressed in spiral ganglion neurons for postnatal development of hearing. J Biol Chem, 286(34):29621-6, 2011.
22. Yajima I, Kumasaka YM, Thang ND, Goto Y, Takeda K, Iida M, Ohgami N, Tamura H, Yamanoshita O, Kawamoto Y, Furukawa K, Kato M. Molecular network associated with MITF on skin melanoma development and progression. J Skin Cancer, 730170, 2011 [review].
23. Toh B, Wang X, Keeble J, Sim WJ, Khoo K, Wong WC, Kato M, Prevost-Blondel A,
24. Thiery JP, Abastado JP. Mesenchymal transition and dissemination of cancer cells is
25. driven by myeloid-derived suppressor cells infiltrating the primary tumor. PLoS Biol, 9(9): e1001162, 2011.
26. Thang ND, Yajima I, Kumasaka MY, Ohnuma S, Yanagishita T, Hayashi R, Shekhar HU, Watanabe D, Kato M. Barium promotes anchorage-independent growth and invasion of human HaCaT keratinocytes via activation of c-SRC kinase. PLoS ONE, 6(10):e25636, 2011.
27. Meyer C, Sevko A, Ramacher M, Bazhin AV, Falk C, Osen W, Borrello I, Kato M, Schadendorf D, Baniyash M, Umansky V. Sildenafil exerts anti-tumor effects and reduces Gr1+CD11b+ cell-mediated immunosuppression in ret transgenic mouse melanoma model. Proc Natl Acad Sci USA, 108(41):17111-6, 2011.
28. Hong M, Puaux AL, Huang C, Loumagne L, Tow C, Mackay C, Kato M, Prevost-Blondel A, Avril MF, Nardin A, Abastado JP. Chemotherapy induces intratumoral expression of chemokines in cutaneous melanoma, favoring T cell infiltration and tumor control. Cancer Res, in press, 2011.
29. Yajima I, Kumasaka YM, Thang ND, Goto Y, Takeda K, Yamanoshita O, Iida M, Ohgami N, Tamura H, Kawamoto Y, Kato M. RAS/RAF/MEK/ERK and PI3K/PTEN/AKT signaling in malignant melanoma progression and therapy. Dermatol Res Prac, 2012:354191, 2012 [review].
30. Thang ND, Yajima I, Nakagawa K, Tsuzuki T, Kumasaka YM, Ohgami N, Thuy LB, Iwamoto T, Watanabe D, Kato M. A novel hairless mouse model for malignant melanoma. J Dermatol Sci, in press, 2012.