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has been cited by the following article:

• TITLE: Facial Skin Rejuvenation with High Frequency Ultrasound: Multicentre Study of Dual-Frequency Ultrasound

  AUTHORS: Dirk Meyer-Rogge, Frank Rösken, Peter Holzschuh, Bruno D’hont, Ilja Kruglikov

  KEYWORDS: Skin Rejuvenation; Dual-Frequency Ultrasound; Matrix Metalloproteinases; Heat Shock Proteins

  JOURNAL NAME: Journal of Cosmetics, Dermatological Sciences and Applications, Vol.2 No.2, June 22, 2012

  ABSTRACT: According to modern theories, the process of skin ageing may be connected with local up-regulation of matrix metalloproteinases (MMP) and down-regulation of heat shock proteins (HSP) in the skin. In this pragmatic, non-randomised, multicentre study we investigated the skin rejuvenation effect of dual-frequency ultrasound, with frequencies of 3 and 10 MHz, which has the ability to modulate both MMPs and HSPs. It was shown that such waves can significantly improve different visual appearances of ageing skin. This safe, non-invasive method yields results that are not as marked as those shown by injecting of fillers, but can be successfully used by subjects with a broad spectrum of visual skin ageing problems, which have to be treated simultaneously.