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https://doi.org/10.1158/0008-5472.CAN-10-4274

has been cited by the following article:

• TITLE: Research Progress of Epigenetics in Liver Cancer

  AUTHORS: Shijian Fu, Min Guo

  KEYWORDS: Epigenetics, Hepatocellular Carcinoma, DNA Methylation, Histone Modification, miRNA Regulation

  JOURNAL NAME: Journal of Cancer Therapy, Vol.15 No.3, March 19, 2024

  ABSTRACT: Epigenetic changes are changes in gene expression by regulating gene transcription and translation without changing the nucleotide sequence of the genome. Although the genome itself changes during the occurrence and development of most malignant tumors, recent studies have found that epigenetic changes also play an important role in the occurrence and development of tumors. Epigenetic modification mainly includes DNA methylation, histone modification and miRNA regulation. This review focuses on the role and mechanism of epigenetic modification in the occurrence, metastasis and invasion of hepatocellular carcinoma (HCC), and summarizes the latest methods for the treatment of HCC by restoring dysregulated epigenetic modification. It provides a theoretical basis for revealing the pathogenesis of liver cancer and developing new methods of diagnosis and treatment.