Drumond, M.M., Tapia-Costa, A.P., Neumann, E., Nunes, á.C., Barbosa, J.W., Kassuha, D.E., et al. (2023) Cell-Free Supernatant of Probiotic Bacteria Exerted Antibiofilm and Antibacterial Activities against Pseudomonas aeruginosa: A Novel Biotic Therapy. Frontiers in Pharmacology, 14, Article ID: 1152588.
https://doi.org/10.3389/fphar.2023.1152588

has been cited by the following article:

• TITLE: Bacterial Exofactors Modulate Biofilm Growth and Resistivity to Antimicrobial Drugs

  AUTHORS: Van Nguyen^#, Bea Penaredondo^#, Girdhari Rijal

  KEYWORDS: Biofilm, Exofactors, Antimicrobial Drugs, Growth, Extracellular Matrix Substance, Microcolonies

  JOURNAL NAME: Advances in Microbiology, Vol.14 No.1, January 15, 2024

  ABSTRACT: Some bacteria have the ability to co-exist, proliferate and survive in a multicellular community, biofilm. Each participating bacteria can form its colonies and encases itself by a self-produced insoluble extracellular matrix substance (EPS). Microcolonies within biofilm are held together by interactions and bonding of the substances present in the EPS with their separation from the water channels. Similar to insoluble EPS, bacterial microcolonies release soluble exofactors that have direct impacts on the survivability, growth and antibacterial resistivity of other microcolonies made of single- or multi-species bacteria in the same biofilm. How the exofactors of microcolonies of one-type bacteria impact on microcolonies of other-type bacteria is still unclear. We studied about the role of exofactors released from Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa, which are common biofilm-forming pathogenic bacteria. Exofactors facilitate to transform the microenvironment where bacteria can acquire alternative lifestyle with a long survival period and resistivity to certain antimicrobial drugs.