TITLE:
Protective Effect of an Anthocyanin on Alzheimer’s Disease
AUTHORS:
Alya Al-Furaydi, Noorah Saleh Al-Sowayan
KEYWORDS:
Anthocyanins, Oxidative Stress, Microglia Activation, NF-κB
JOURNAL NAME:
Advances in Bioscience and Biotechnology,
Vol.14 No.12,
December
21,
2023
ABSTRACT: Alzheimer’s, characterized by β-amyloid
accumulation and tau hyperphosphorylation, is linked to inflammation, oxidative
stress, and microglial activation, suggesting potential protective strategies.
Studies have shown that natural polyphenolic anthocyanin components found in
berries, such as cyanidin, can inhibit amyloid filament formation and modulate
Alzheimer’s disease are polyphenolic flavonoids, which are responsible for red,
purple, and blue colors in various fruits, such as red cabbage and most
berries. Here, we reviewed the protective effects of anthocyanins. It has
anti-inflammatory and antioxidant properties, reduces NF-κB, and affects inflammatory signaling pathways. They also improve
cognitive function, making them a potential protective strategy against AD.