Krenek, P., Kmecova, J., Kucerova, D., Bajuszova, Z., Musil, P., Gazova, A., Ochodnicky, P., Klimas, J. and Kyselovic, J. (2009) Isoproterenol-Induced Heart Failure in the Rat Is Associated with Nitric Oxide-Dependent Functional Alterations of Cardiac Function. European Journal of Heart Failure, 11, 140-146.
https://doi.org/10.1093/eurjhf/hfn026

has been cited by the following article:

• TITLE: A Cardiomyopeptin Preparation Protects against Isoproterenol-Induced Chronic Heart Failure in Rats

  AUTHORS: Zumeng Xia, Hoi Yan Leung, Hoi Ling Siu, Chung Wai Chan, Kam Ming Ko

  KEYWORDS: Cardiomyopeptin, Herbal Extract, Chronic Heart Failure, Isoproterenol

  JOURNAL NAME: Chinese Medicine, Vol.14 No.4, November 24, 2023

  ABSTRACT: The present study investigated the effect of an herbal extract-supplemented cardiomyopeptin preparation (HECP), in the rat model of chronic heart failure. HECP pre-/co-treatment at a daily dose of 0.072 to 0.124 g/kg for 30 days protected against isoproterenol (ISO)-induced chronic myocardial damage in rats in a dose-dependent manner, with the extent of protection, as assessed by plasma cardiac troponin I level, being up to 76%. The cardioprotection afforded by HECP was associated with the enhancement of myocardial mitochondrial antioxidant status, amelioration of plasma parameters on cardiac dysfunction and hypertrophy, as well as an increase in myocardial endothelial nitric oxide synthase activity. Myocardial apoptotic and anti-apoptotic parameters were suppressed and stimulated, respectively. The cardioprotection afforded by HECP was accompanied by an increase in exercise capacity, an indirect functional index of the myocardium, in ISO-challenged rats. In conclusion, HECP may offer a promising prospect in preventing chronic heart failure in human subjects.