Khoshnood, S., Heidary, M., Asadi, A., Soleimani, S., Motahar, M., Safari, M., Saki, M. and Abdi, M. (2019) A Review of Mechanism of Action, Resistance, Synergism, and Clinical Implications of Mupirocin against Staphylococcus aureus. Biomedicine & Pharmacotherapy, 109, 1809-1818.
https://doi.org/10.1016/j.biopha.2018.10.131

has been cited by the following article:

• TITLE: Is the Prophylactic Administration of Povidone Iodine Intranasally Preoperatively in Elective Total Knee Replacement as Effective as MRSA Prophylactic Screening and Mupirocin Treatment?—A Retrospective Analysis

  AUTHORS: Teddy Theodorakis

  KEYWORDS: Povidone Iodine, MRSA, Mupirocin, Total Knee Replacement

  JOURNAL NAME: Open Journal of Orthopedics, Vol.13 No.7, July 31, 2023

  ABSTRACT: Surgical Site Infections (SSIs) remain a prevalent issue in healthcare. An average of 2% to 4% of all Total Knee Arthroplasties (TKA/TKR) result in a Prosthetic Joint Infection (PJI) (Ashraf et al. , 2018). These surgical site infections cause significant distress to the patient and require extended courses of antibiotic treatment and revision surgery of the infected joint. SSIs also reduce financial reimbursement to the surgery facility and affect the performing surgeon’s performance scores. To prevent surgical infection, healthcare facilities have implemented various screening or decolonization methods to prevent surgical infection to may cause infection. Various treatment methods exist for managing MRSA preoperatively which include Povidone Iodine (PI) application as a universal decolonization method and/or screening every patient pre-operatively for MRSA and treating MRSA-positive patients with Mupirocin ointment. Both interventions are well-established in the literature. At the author’s facility, the elective TKR populations were analyzed while each intervention was implemented. In 2019 TKR patients underwent MRSA swabbing and testing and in 2021 PI decolonization was the decolonization method of choice. The study revealed that MRSA testing and swabbing were better at reducing SSI related to MRSA than Povidone Iodine decolonization.