TITLE:
Lung Hyperinflation Is Associated with Pulmonary Exacerbations in Adults with Cystic Fibrosis
AUTHORS:
Kosal Seng, Lynn Fukushima, Pooja Patel, Arteen Pirverdian, Adupa Rao, Joseph Milic-Emili, Ahmet Baydur
KEYWORDS:
Cystic Fibrosis, Hyperinflation, Inspiratory Capacity, Quality of Life
JOURNAL NAME:
Open Journal of Respiratory Diseases,
Vol.6 No.2,
May
9,
2016
ABSTRACT: Background: Forced expiratory volume 1 second (FEV1) has traditionally been used as a readily
available marker of health in adult cystic fibrosis (CF). However, due to the obstructive nature of
this disease, it is possible that lung hyperinflation could be more closely related to disease severity
than is FEV1. The purpose of this study was to determine if hyperinflation is more closely associated
with quality of life, functional status, and pulmonary exacerbations than FEV1 in patients
with CF. Methods: Sixty-eight adult patients with CF were evaluated in this retrospective study. We
used IC and functional residual capacity (FRC) and their ratios to total lung capacity (TLC) as
measures of lung hyperinflation. We used bivariate correlations and backwards regression analysis
to assess possible associations between FEV1, lung hyperinflation, and measures of disease severity
including questionnaire based quality of life, pulmonary exacerbation frequency, and mortality.
The respiratory component of the Cystic Fibrosis Questionnaire–Revised (CRQ-R-Respiratory)
was used as a measure of quality of life. Results: Both FEV1 and IC were negatively correlated
with pulmonary exacerbations over a 3 year period (p = 0.004, r2 = 0.127; p Conclusions: FEV1 and lung hyperinflation-as measured by IC and
FRC/TLC-are both associated with pulmonary exacerbation frequency. This suggests that chronic
dynamic hyperinflation contributes significantly to disease severity in adult cystic fibrosis.