TITLE:
Oxidative Stress and Post-Ischemic Inflammatory Response in Ischemic Stroke Complicated with Diabetes Mellitus Type 2
AUTHORS:
Gohar Tsakanova, Elina Arakelova, Armine Soghoyan, Violetta Ayvazyan
KEYWORDS:
Oxidative Stress, Postischemic Inflammatory Response, Cytokines, Ischemic Stroke, Diabetes Mellitus
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.3 No.3,
March
18,
2015
ABSTRACT:
Oxidative stress and post-ischemic inflammatory
response are the key pathogenic mechanisms of the neuronal injury caused by
ischemic stroke (IS). On the other hand, Diabetes is a major risk factor for
the development of stroke, increasing the susceptibility to atherosclerosis and
the prevalence of atherogenic risk factors, including hypertension, obesity,
and abnormal blood lipids. The aim of current study was to analyze the
functional activity of oxidant-antioxidant system and post-ischemic
inflammatory response in IS patients complicated and noncomplicated with diabetes
mellitus type 2 (DM2). ELISA, photochemiluminescent and spectrophotometric
methods were used to analyze the serum samples of IS patients complicated and
noncomplicated with DM2, DM2 patients, as well as healthy subjects. The results
obtained suggest that IS complicated with diabetes is characterized by higher
intensity of the lipid peroxidation process as compared to IS noncomplicated
with diabetes that, probably, is one of the determining factors responsible for
more severe clinical course of IS patients complicated with DM2 compared to
those noncomplicated with DM2. It is also shown that mechanisms of the
compensatory response to oxidative stress on the level of antioxidants in IS
patients complicated with diabetes differ from those detected in IS
noncomplicated with diabetes. A significant increase of the levels of the five
analyzed cytokines in both groups of IS patients were detected. Based on the
results obtained we suggest that metabolic, molecular, and cellular level alterations
are typical for long-term DM2 impair compensatory mechanisms protecting the
body from oxidative stress, and that in IS complicated with DM2 the systemic
inflammatory reactions and oxidative stress are more intense than in case of IS
noncomplicated with DM2.