New Matrix Tablet from Okra Gum: Effects of Method of Preparation and Gum Concentration on Tablet Properties

Bakre Lateef Gbenga, Abimbola Zulikha

Department of Pharmaceutics and Pharmaceutical Technology, Olabisi Onabanjo University, Sagamu, Nigeria.
Department of Pharmaceutics and Pharmaceutical Technology, Olabisi Onabanjo University, Sagamu, Nigeria..

DOI: 10.4236/pp.2013.46070                

Abstract

The objective of this investigation is to study the effect of methods of preparation and concentration of gum on the compressional and mechanical properties of Okra gum matrix. The compressional behavior of Okra gum matrices prepared by direct compression and wet granulations is analyzed using density measurements, Heckel and Kawakita analysis while the mechanical properties of the formulations were assessed using crushing strength (CS) and friability (FR) as well as CSFR ratio. Formulations prepared by direct compression had lower Pk values than those prepared by wet granulation while there was no significant difference between Py values of formulations prepared by direct compression and wet granulations. Therefore, formulations prepared by direct compression underwent plastic deformation more easily and rapidly than those prepared by wet granulation. The results show that DB values increased with decrease in concentration of the gum and granules undergo higher degree of fragmentation than powders. Formulations containing 90% w/w Okra gum exhibited the highest amount of total plastic deformation and gave the best packing. Tablets prepared by direct compression showed lower bond strength and higher friability values than those prepared by wet granulations. The crushing strength generally decreases with a decrease in the concentration of the gum while there was an inverse relationship between friability and gum concentration. CSFR decreases with a decrease in gum concentration and tablets prepared by wet granulations showed significantly higher values of CSFR (p < 0.001) than those prepared by direct compression. The results suggest that the concentration of gum and the method of preparation of materials for compression are critical factors in the formulation of Okra gum matrices with acceptable compressional and mechanical properties.

Keywords

Okra Gum; Wet Granulation; Direct Compression; Compressional and Mechanical Properties

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	A. Jain, Y. Gupta and S. K. Jain, “Perspectives of Biodegradable Natural Polysaccharides for Site-Specific Drug delivery to the colon,” Journal of Pharmacy & Pharmaceutical Sciences, Vol. 10, No. 1, 2007, pp. 86-128. www.cspsCanada.org
[2]	P. B. Malafaya, G. A. Silva and R. L. Reis, “NaturalOrigin Polymers as Carriers and Scaffolds for Biomolecules and Cell Delivery in Tissue Engineering Applications,” Advanced Drug Delivery Reviews, Vol. 59, No. 4-5, 2007, pp. 207-233. doi:10.1016/j.addr.2007.03.012
[3]	A. Shirwaikar, S. L. Prabu and G. A. Kumar, “Herbal Excipients in Novel Drug Delivery Systems,” Indian Journal of Pharmaceutical Sciences, Vol. 70, No. 4, 2008, pp. 415-422. doi:10.4103/0250-474X.44587
[4]	C. E. Beneke, A. M. Viljoen and J. H. Hamman, “Polymeric Plant-Derived Excipients in Drug Delivery,” Molecules, Vol. 14, No. 7, 2009, pp. 2602-2620. doi:10.3390/molecules14072602
[5]	P. F. Builders, M. B. Agbo, T. Adelakun, L. C. Okpako and A. A. Attama, “Novel Multifunctional Pharmaceutical Excipients Derived from Microcrystalline CelluloseStarch Microparticulate Composites Prepared by Compatibilized Reactive Polymer Blending,” International Journal of Pharmaceutics, Vol. 388, No. 1-2, 2010, pp. 159-167. doi:10.1016/j.ijpharm.2009.12.056
[6]	J. A. Boustra and H. E. Junginger, “Hydrogels,” In: J. Swarbrick and J. C. Boylan, Eds., Encyclopedia of Pharmaceutical Technology Vol. 7, Marcel Dekker, Inc., New York, 1993, p. 441.
[7]	R. C. Rowe, P. J. Shesky and M. E. Quinn, “Hand Book of Pharmaceutical Excipients,” 4th Edition, Pharmaceutical Press, London, 2003.
[8]	M. Agarwal, R. Srinivasan and A. Mishra, “Study on Flocculation Efficiency of Okra Gum in Sewage Waste Water,” Macromolecular Materials and Engineering, Vol. 286, No. 9, 2001, pp. 560-563. doi:10.1002/1439-2054(20010901)286:9<560::AID-MAME560>3.0.CO;2-B
[9]	N. Tavakoli, N. Ghasemi, R. Taimouri and H. Hamishehkar, “Evaluation of Okra Gum as a Binder in Tablet Dosage Forms,” Iranian Journal of Pharmaceutical Research, Vol. 3, Suppl. 2, 2004, pp. 47-49.
[10]	M.O Emeje, C. Y. Isimi and O. O. Kunle, “Evaluation of Okra Gum as a Dry Binder in Paracetamol Tablet Formulations,” Continental Journal of Pharmaceutical Sciences, Vol. 1, 2007, pp. 15-22.
[11]	V. D. Kalu, M. A. Odeniyi and K. T. Jaiyeoba, “Matrix Properties of a New Plant Gum in Controlled Drug Delivery,” Archives of Pharmacal Research, Vol. 30, No. 7, 2007, pp. 884-889. doi:10.1007/BF02978841
[12]	M. M. Talukdar, A. Michoel, P. Rombant and R. Kinget “Comparative Study on Xanthum Gum and Hydroxypropylmethyl Cellulose as Matrices for Controlled Release Drug Delivery. I. Compaction and in Vitro Drug Release Behavior,” International Journal of Pharmaceutics, Vol. 129, No. 1-2, 1996, pp. 233-241. doi:10.1016/0378-5173(95)04355-1
[13]	J. M. Sonnergaard,” A Critical Evaluation of the Heckel Equation,” International Journal of Pharmaceutics, Vol. 193, No. 1, 1999, pp. 63-71. doi:10.1016/S0378-5173(99)00319-1
[14]	I. Krycer, D. G. Pope and J. A. Hersey, “The Interpretation of Powder Compaction Data—A Critical Review,” Drug Development and Industrial Pharmacy, Vol. 8, No. 3, 1982, pp. 307-342. doi:10.3109/03639048209022103
[15]	T. Comoglu, “An Overview of Compaction Equations,” Journal Faculty of Pharmacy, Vol. 36, No. 2, 2007, pp. 123-133.
[16]	W. Heckel, “Density-Pressure Relationship in Powder Compaction,” Transactions of the Metallurgical Society of AIME, Vol. 221, 1961, pp. 671-675.
[17]	K. Kawakita and K. H. Ludde, “Some Considerations on Powder Compression Equations,” Powder Technology, Vol. 4, No. 2, 1971, pp. 61-68.
[18]	G. Alderborn and C. Nystrom, “Studies on Direct Compression of Tablets. IV. The Effect of Particle Size on the Mechanical Strength of Tablets,” Acta Pharmaceutica Suecica, Vol. 19, No. 5, 1982, pp. 381-390.
[19]	O. O. Odeku and O. A. Itiola, “Evaluation of Khaya Gum as a Binder in a Paracetamol Tablet Formulation,” Pharmacy and Pharmacology Communications, Vol. 4, No. 4, 1998, pp. 183-188.
[20]	P. Shivanand and O. L. Sprokel, “Compaction Behaviour of Cellulose Polymers,” Powder Technology, Vol. 69, No. 2, 1992, pp. 177-184. doi:10.1016/0032-5910(92)85072-4
[21]	F. Podczeck and M. Sharma, “The Influence of Particle Size and Shape of Components of Binary Powder Mixtures on the Maximum Volume Reduction Due to Packing,” International Journal of Pharmaceutics, Vol. 134, No. 1, 1996, pp. 41-47. doi:10.1016/0378-5173(95)04420-5
[22]	O. O. Odeku and O. A. Itiola, “Evaluation of the Effects of Khaya Gum on the Mechanical and Release Properties of Paracetamol Tablets,” Drug Development and Industrial Pharmacy, Vol. 29, No. 3, 2003, pp. 311-320. doi:10.1081/DDC-120018205
[23]	J. Sujja-Areavath, D. L. Munday, P. J. Cox and K. A. Khan, “Release Characteristics of Diclofenac Sodium from Encapsulated Natural Gum Mini-Matrix Formulations,” International Journal of Pharmaceutics, Vol. 139, 1996, pp. 53-62. doi:10.1016/0378-5173(96)04573-5