Article citationsMore>>
D. B. Lombard, F. W. Alt, H. L. Cheng, J. Bunkenborg, R. S. Streeper, R. Mostoslavsky, J. Kim, G. Yancopoulos, D. Valenzuela, A. Murphy, et al., “Mammalian Sir2 Homolog SIRT3 Regulates Global Mitochondrial Lysine Acetylation,” Molecular and Cellular Biology, Vol. 27, No. 24, 2007, pp. 88078814. doi:10.1128/MCB.01636-07
has been cited by the following article:
-
TITLE:
The Sirtuins in Aging and Metabolic Regulation
AUTHORS:
T. C. LaGuire, S. K. Reaves
KEYWORDS:
Aging; Sirtuins; SIR-2; SIRT1; SIRT3; SIRT4; SIRT5; SIRT6; NF-kB; Metabolic Regulation
JOURNAL NAME:
Food and Nutrition Sciences,
Vol.4 No.6,
June
13,
2013
ABSTRACT: Numerous theories of how and why aging occurs have been postulated but a definitive comprehensive explanation remains elusive. Attempts to unravel genetic details of aging resulted in the identification of a yeast gene known as Sir2 as a modulator of life span. Identification and characterization of mammalian Sir2 homologs followed and has catapulted aging research to exciting new levels. This review begins with basic definitions of aging and then describes some of the most common theories of the aging process. The review presents information related to the initial discovery of the Sirtuins and summarizes some of the recent advances in defining roles for Sirtuin family members. SIRT6 is discussed in greater detail because it is one of the best characterized of the mammalian Sirtuins and seems to be one of the most important in the aging process and metabolic regulation.
Related Articles:
-
Xiaoyu Liu, Duyun Peng, Youdong Wen
-
Mukeba Mbala Eric, Shiwei Xu, Wen Yu, Shengwei Wang, Abdul-Gafar Ahmed, Siek Darith, Mujinga Bukasa Eliane
-
Ekerette Emmanuel Ekerette, Ekei Victor Ikpeme, Ogbuagu Ugorji Udensi, Michael Ohiokhuaobo Ozoje, Owoidihe Monday Etukudo, Anthony John Umoyen, Samuel Olutunde Durosaro, Matthew Wheto
-
Junfeng Gao, Lan Jiang
-
Lijun Liu