Article citationsMore>>
Collins, A.F., Fassos, F.F., Stobie, S., Lewis, N., Shaw, D., Fry, M., Templeton, D.M., McClelland, R.A., Koren, G. and Olivieri, N.F. (1994) Iron-balance and dose-response studies of the oral iron chelator 1,2-dimethyl- 3-hydroxypyrid-4-one (L1) in iron-loaded patients with sickle cell disease. Blood, 83, 2329-2333.
has been cited by the following article:
-
TITLE:
Evaluation of a novel oral iron chelator 1-(N-acetyl-6-aminohexyl)-3-hydroxypyridin-4-one (CM1) for treatment of iron overload in mice
AUTHORS:
Somdet Srichairatanakool, Kanjana Pangjit, Chada Phisalaphong, Suthat Fucharoen
KEYWORDS:
Thalassemia; Iron Overload; Iron Chelator; Hydroxypyridinone; Lipid Peroxidation; Malondialdehyde
JOURNAL NAME:
Advances in Bioscience and Biotechnology,
Vol.4 No.2,
February
28,
2013
ABSTRACT:
Desferrioxamine
(DFO), deferiprone (DFP) and deferasirox (DFX) are promising effective iron
chelators for the treatment of iron overload in b-thalassemia patients; nonetheless, their side effects
have also been reported. 3-Hydroxypyridinone derivatives are being developed as
a safer new chelator and in combined chelation therapy. We evaluated the
iron-chelating activity of 1-(N-acetyl-6-aminohexyl)-3-hydroxypyridin-4-one (CM1) in
iron-loaded C57BL6 mice. The feeding of a ferrocene-supplemented diet (Fe diet)
to mice resulted in iron overload, detectable plasma nontransferrin-bound iron
(NTBI) and labile plasma iron (LPI), and increases of red cell membrane iron,
plasma malondialdehyde (MDA) and excessive tissue iron deposits. Like DFP, the
CM1 lowered the levels of the membrane non-heme iron, the NTBI and LPI (p
Related Articles:
-
Kanjana Pangjit, Ratana Banjerdpongchai, Chada Phisalaphong, Suthat Fucharoen, Somdet Srichairatanakool
-
Michihide Tokuhira, Morihiko Sagawa, Reiko Watanabe, Tomoe Nemoto, Takeshi Tomikawa, Shigehisa Mori, Masahiro Kizaki
-
E. Leila Jerome Clay, Alison Motsinger-Reif, Janelle Hoskins, Lindsay Veit, Ali Calikoglu, Rupa Redding-Lallinger
-
Lucie Charlotte Ollandzobo Ikobo, Hardy Maryse Ibovi Gataud, Steve Vassili Missambou Mandilou, Olivia Firmine Galiba Atipo-Tsiba, Rolf Iwandza, Jean Robert Mabiala Babela
-
Mame Saloum Coly, Mouhamadou Mansour Diagne, Jean Fidele Nnang Essone, Abdou Khadir Sow, Salimata Diagne Houndjo, Maimouna Toure, Aïssatou Seck, Awa Ba, Abdoulaye Ba, Abdoulaye Samb, Moussa Seck, Saliou Diop, Mor Diaw, Fatou Bintou Sar, Arame Mbengue