TITLE:
Aminated Cyclopropylmethylphosphonates as Potent Prostate Cancer Inhibitors
AUTHORS:
Abed Al Aziz Al Quntar, Ibrahim Abasy
KEYWORDS:
Prostate Cancer, Cancer, Cyclopropylphophonates, Aminophosphonates, Cyclopropanes, Phosphonates, Alkynylphosphonates, Anti-Cancer, Prostate
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.12 No.7,
July
23,
2024
ABSTRACT: Inspired by the anti-pancreatic promising results of our novel aminated cyclopropylmethylphosphonate compounds, an in vitro anti-prostate cancer activity exploration of these compounds was carried out on human prostate cancer cell line PC-3, and showed potent inhibiting activity at low micromolar concentrations (with an IC50 of approximately 45 μM).