Article citationsMore>>
Bonner, J.A., Harari, P.M., Giralt, J., Cohen, R.B., Jones, C.U., Sur, R.K., Raben, D., Baselga, J., Spencer, S.A., Zhu, J., Youssoufian, H., Rowinsky, E.K. and Ang, K.K. (2010) Radiotherapy Plus Cetuximab for Locoregionally Advanced Head and Neck Cancer: 5-Year Survival Data from a Phase 3 Randomised Trial, and Relation between Cetuximab-Induced Rash and Survival. The Lancet Oncology, 11, 21-28.
https://doi.org/10.1016/S1470-2045(09)70311-0
has been cited by the following article:
-
TITLE:
Association between Subjective Evaluation of Skin Toxicities and Quality of Life in Patients with Lung Cancer Undergoing Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor Treatment: A Pilot Study for Developing Skin Toxicity Assessment
AUTHORS:
Kengo Hirayama, Ya Su, Yasuyuki Ikezawa, Megumi Chiba, Kenichiro Ito, Michiko Yuki
KEYWORDS:
Lung Cancer, EGFR-Tyrosine Kinase Inhibitors, Skin Toxicity, Quality of Life
JOURNAL NAME:
Open Journal of Nursing,
Vol.9 No.12,
December
18,
2019
ABSTRACT: Purposes: Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) exert satisfactory therapeutic effects in lung cancer patients. However, the resultant skin toxicity can deteriorate patients’ quality of life (QoL). Differences exist in skin toxicity evaluation between patients and clinicians. We aimed to clarify the association between the subjective evaluation of skin toxicities and QoL in lung cancer patients and to establish a document of scale development in the subjective evaluation of skin toxicity. Methods: We used self-administered questionnaires to evaluate 12 lung cancer patients receiving EGFR-TKI treatment. Indices of QoL were generated using the Functional Assessment of Cancer Therapy-Lung and Hospital Anxiety and Depression Scale, and a subjective evaluation questionnaire concerning skin toxicity was completed. The data were collected immediately before treatment initiation and at 4 weeks post treatment. Results: In the subjective evaluation of skin toxicity, four patients (33.3%) were classified as ≥Grade 2 (painful group), experiencing painful pruritus at the emergence site of the skin rash or xerosis. In this group, the QoL scores of physical and emotional aspects declined after treatment. Conversely, patients in the painless group (Grade 0 - 1) demonstrated an improved emotional QoL following treatment (p = 0.028). Conclusions: Lung cancer patients suffering from painful skin toxicity tended to show a decline in the physical and emotional aspects of QoL following EGFR-TKI treatment. The skin toxicity questionnaire was useful from the point of view of a subjective evaluation and could be a powerful assessment tool in future clinical settings with further modification.
Related Articles:
-
Guy N’da, Amine Lachgar, Oswald Houessou, Sanae El Majjaoui, Hanane El Kacemi, Tayeb Kebdani, Nourredine Benjaafar
-
Yuka Uemura, Sachiko Sugimoto, Katsuyoshi Matsunami, Hideaki Otsuka, Yoshio Takeda
-
Kozo Kataoka, Akiyoshi Kanazawa, Akio Nakajima, Hisahiro Hosogi, Seiichiiro Kanaya, Takeshi Nagasaka, Yukihiro Kono
-
Toshikazu Moriwaki, Tetsuya Eto, Akihito Tsuji, Nobushige Kakinoki, Mitsuo Shimada, Takashi Maeba, Hiroaki Hatano, Ikuo Takahashi, Hiroyasu Ishida, Kazuho Ikeda, Yoshiaki Bando, Ichinosuke Hyodo
-
Moawwad E. A. El-Mikkawy