Article citationsMore>>
Dimmock, J.R., Kumar, P., Nazarali, A.J., Motaganahalli, N.L., Kowalchuk, T.P., Beazely, M.A., Wilson Quail, J., Oloo, E.O., Allen, T.M., Szydlowski, J., DeClercq, E. and Balzarini, J. (2000) Cytotoxic 2,6-Bis(Arylidene)Cyclohexanones and Related Compounds. European Journal of Medicinal Chemistry, 35, 967-977.
https://doi.org/10.1016/S0223-5234(00)01173-9
has been cited by the following article:
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TITLE:
Molecular Modeling and Synthesis of New Heterocyclic Compounds Containing Pyrazole as Anticancer Drugs
AUTHORS:
Fiby N. Takla, Abdelbasset A. Farahat, Magda A.-A. El-Sayed, Magda N. A. Nasr
KEYWORDS:
Tubulin, CA-4, Anticancer, Pyrazole, Molecular Modeling
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.7 No.4,
December
15,
2017
ABSTRACT: Several modifications in CA-4 were reported in
literature for the development of various tubulin inhibitors. In our study,
twenty-two newly synthesized heterocyclic derivatives of Combretastatin A-4
(CA-4) have been tested for their cytotoxic effect on four different types of
cells with malignant behavior using CA-4 as a positive control. Compounds 5b, 15 and 16 showed the foremost potent antiproliferative activities
as compared to CA-4 with IC50 starting from 6.9 to 13.7 μM. Molecular docking
was performed with the crystal structure of tubulin employing a potent tubulin
inhibitor CA-4 as a parent molecule. Molecular study advised that 5b, 15, 16 and 17 are promising tubulin inhibitors.
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