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Moro, E., Lozano, A.M., Pollak, P., Agid, Y., Rehncrona, S., Volkmann, J., Kulisevsky, J., Obeso, J.A., Albanese, A., Hariz, M.I., Quinn, N.P., Speelman, J.D., Benabid, A.L., Fraix, V., Mendes, A., Welter, M.L., Houeto, J.L., Cornu, P., Dormont, D., Tornqvist, A.L., Ekberg, R., Schnitzler, A., Timmermann, L., Wojtecki, L., Gironell, A., Rodriguez-Oroz, M.C., Guridi, J., Bentivoglio, A.R., Contarino, M.F., Romito, L., Scerrati, M., Janssens, M. and Lang, A.E. (2010) Long-Term Results of a Multicenter Study on Subthalamic and Pallidal Stimulation in Parkinson’s Disease. Movement Disorders, 25, 578-586.
http://dx.doi.org/10.1002/mds.22735
has been cited by the following article:
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TITLE:
Five-Year Outcomes of Bilateral Subthalamic Nucleus Stimulation in Japanese Patients with Parkinson’s Disease
AUTHORS:
Atsushi Umemura, Miwako Miyata, Yuichi Oka, Kenji Okita, Genko Oyama, Yasushi Shimo, Nobutaka Hattori
KEYWORDS:
Deep Brain Stimulation, Subthalamic Nucleus, Parkinson’s Disease, Long-Term Outcome, Adverse Effect
JOURNAL NAME:
Advances in Parkinson's Disease,
Vol.4 No.2,
April
10,
2015
ABSTRACT: Background: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is widely performed for medically refractory Parkinson’s disease (PD). Several western studies have examined the long-term outcomes of STN DBS. However, the long-term outcomes in Japanese patients have not been reported. Methods: We studied the long-term outcomes of STN DBS in Japanese patients with PD. Fifty-five consecutive patients treated with bilateral STN DBS were followed for 5 years after surgery. Each patient underwent Unified Parkinson’s Disease Rating Scale assessments preoperatively and 1 and 5 years after surgery. Results: Twelve patients (22%) were lost to follow up within 5 years. Among them, 7 died and 5 became bed ridden because of PD deterioration. In the 43 patients followed for 5 years, STN DBS significantly improved motor function. The cardinal motor symptoms of tremor, rigidity, and bradykinesia in medication-on periods were significantly better than baseline 5 years after DBS. However, axial motor symptoms of speech, gait and postural stability gradually deteriorated and significantly worsened 5 years after DBS. Motor complications, including dyskinesia and motor fluctuations, significantly improved after DBS with a marked reduction in dopaminergic medication. These effects were maintained 5 years after DBS. Frequently, persisting adverse effects included apraxia of eyelid opening and dysarthria. Conclusions: STN DBS significantly improved motor symptoms in patients with advanced PD. These effects were maintained over 5 years in most patients. However, some showed rapid PD progression even after STN DBS. Other treatments for the axial symptoms and disease progression are needed in long-term PD treatment.
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