TITLE:
Assessment of Sub-Endometrial Junction Zone by 3-Dimensional Transvaginal Ultrasound in Unexplained Recurrent Implantation Failure and Its Effect on ICSI Outcomes
AUTHORS:
Abd El-Naser Abd El-Gaber Ali, Syed A. Taha, Mohammed F. Abd El-Ghany, Mustafa M. Khodry, Ahmed M. Abbas
KEYWORDS:
Three Dimensional Trans-Vaginal Ultrasound, Junction Zone, ICSI, Recurrent Implantation Failure
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.9 No.1,
January
14,
2019
ABSTRACT: BACKGROUND: Sub-endometrial junction zone (JZ) plays an important role in most of
reproductive functions. OBJECTIVE: To find
out the effect of the sub-endometrial JZ thickness assessment by 3-D
trans-vaginal ultrasound (TVUS) on
intracytoplasmic sperm injection (ICSI)
outcomes in patients with unexplained recurrent implantation failure (RIF). SETTING: ART Unit of Obstetrics and Gynecology Department, Faculty of Medicine, South
Valley University, Qena, Egypt. DURATION: From April 2016 to October
2018. STUDY DESIGN: A prospective observational study. METHDS: Fifty couples
with history of unexplained RIF in previous ICSI cycles and prepared for another
ICSI cycle (group I) and fifty couples with unexplained infertility prepared
for ICSI for the first time (group II) had been included in this study. At time
of ovum pick up, 3-DTVUS was done for all cases in both groups for assessment of sub endometrial
junction zone thickness and correlated with ICSI outcome. RESULTS: There
were statistically significant differences between group I and group II in JZ
thickness in the 3 uterine regions (fundus, anterior and posterior walls) with
p 0.001, but there were mildly statistically significant differences
between both groups in chemical and clinical pregnancy rates with p CONCLUSIONS: The thickness of JZ in patients with history of
unexplained RIF was higher than those with unexplained infertility scheduled
for ICSI. The JZ thickness was inversely correlated with increased embryo
implantation rates in ICSI procedures, the thinner the JZ thickness was
associated with higher pregnancy rates (both chemical and clinical pregnancy
rates).