Prof. Rob Krams
Imperial College London, UK
Professor
Email: r.krams@imperial.ac.uk
Qualifications
1990-1993 Post Doc, ErasmusMC Rotterdam, the Netherlands
1988-1990 Post Doc, John Hopkins Medical Institutions, USA
1984-1988 PhD, Free University Amsterdam, the Netherlands
Publications (Slected)
-
van Bochove, G.S., et al., Contrast enhancement by differently
sized paramagnetic MRI contrast agents in mice with two phenotypes of
atherosclerotic plaque. Contrast Media Mol Imaging, 2010.
-
Debernardi, N., et al., Microcalcifications in atherosclerotic
lesion of apolipoprotein E-deficient mouse. Int J Exp Pathol, 2010.
-
Plata, A.M., S.J. Sherwin,
and R. Krams, Endothelial nitric oxide production and transport in flow
chambers: The importance of convection. Ann Biomed Eng, 2010. 38(9): p.
2805-2816.
-
Helderman, F., et al.,
Predicting patient-specific expansion of abdominal aortic aneurysms. Eur J
Vasc Endovasc Surg, 2010. 40(1): p. 47-53.
-
Friedman, M.H., R. Krams, and K.B. Chandran, Flow interactions with cells
and tissues: cardiovascular flows and fluid-structure interactions. Sixth
International Bio-Fluid Mechanics Symposium and Workshop, March 28-30, 2008,
Pasadena, California. Ann Biomed Eng, 2010. 38(3): p. 1178-1187.
-
van Bochove, G.S., et al., MRI-determined carotid artery flow
velocities and wall shear stress in a mouse model of vulnerable and stable
atherosclerotic plaque. MAGMA, 2010. 23(2): p. 77-84.
-
Foin, N., et al., SHEAR STRESS AND MASS TRANSPORT AFFECTS NF
kappa B DYNAMICS IN ENDOTHELIAL CELLS. J PHYSIOL SCI, 2009. 59: p.
324-324.
-
Friedman, M.H., R. Krams, and K.B. Chandran, Flow Interactions with Cells
and Tissues: Cardiovascular Flows and Fluid-Structure Interactions : Sixth
International Bio-Fluid Mechanics Symposium and Workshop, March 28-30, 2008,
Pasadena, California. Ann Biomed Eng, 2010.
-
Chaudhury, H., et al.,
c-Jun N-terminal kinase primes endothelial cells at atheroprone sites for
apoptosis. Arterioscler Thromb Vasc Biol, 2010. 30(3): p. 546-553.
-
Krams, R., et al., Shear stress is associated with markers of
plaque vulnerability and MMP-9 activity. EuroIntervention, 2006. 2(2): p.
250-256.
-
Zakkar, M., et al., Activation of Nrf2 in endothelial
cells protects arteries from exhibiting a proinflammatory state. Arterioscler
Thromb Vasc Biol, 2009. 29(11): p. 1851-1857.
-
Cheng, C., et al., Activation of MMP8 and MMP13 by angiotensin
II correlates to severe intra-plaque hemorrhages and collagen breakdown in
atherosclerotic lesions with a vulnerable phenotype. ATHEROSCLEROSIS, 2009.
204(1): p. 26-33.
-
de Crom, R., et al., Large variations in absolute wall shear
stress levels within one species and between species. ATHEROSCLEROSIS, 2009.
204(1): p. 16-17.
-
Susa, D., et al., Donor pre-treatment with tacrolimus reduces
transplant vasculopathy. PHARMACOL RES, 2009. 59(4): p. 273-278.
-
Robbers-Visser, D., et al., Pulmonary Artery Size and Function
After Fontan Operation at a Young Age. J MAGN RESON IMAGING, 2008. 28(5): p.
1101-1107.
-
Segers, D., P. Weinberg, and R. Krams, Atherosclerosis: cell
biology and lipoproteins--shear stress and inflammation in plaque formation:
new evidence. Curr Opin Lipidol, 2008. 19(6): p. 627-628.
-
Helderman, F., et al., A numerical model to predict abdominal
aortic aneurysm expansion based on local wall stress and stiffness. MED BIOL ENG COMPUT,
2008. 46(11): p. 1121-1127.
-
Segers, D., et al., A primer on the immune system in the
pathogenesis and treatment of atherosclerosis. EuroIntervention, 2008. 4(3): p.
378-390.
-
Krams, R., M. Breeuwer, and F. van de Vosse, Personalised
imaging and biomechanical modelling of large vessels. Med Biol Eng Comput,
2008. 46(11): p. 1057-1058.
-
Breeuwer, M., et al., Towards patient-specific risk assessment
of abdominal aortic aneurysm. Med Biol Eng Comput, 2008. 46(11): p.
1085-1095.
-
Ridger, V., et al., Hemodynamic parameters regulating vascular
inflammation and atherosclerosis: a brief update. Biomed Pharmacother, 2008.
62(8): p. 536-540.
-
Zakkar, M., et al., Increased endothelial mitogen-activated
protein kinase phosphatase-1 expression suppresses proinflammatory activation
at sites that are resistant to atherosclerosis. CIRC RES, 2008. 103(7): p.
726-732.
-
Cheng, C., et al., Rapamycin modulates the eNOS vs. shear
stress relationship. CARDIOVASC RES, 2008. 78(1): p. 123-129.
-
da Silva, R.F., et al., Role of arginase pathway in response
to shear stress: new potential therapeutic targets for atherosclerosis? EUR J
CLIN INVEST, 2008. 38: p. 36-36.
-
Foin, N., P. Evans, and R. Krams, Atherosclerosis: cell biology
and lipoproteins - new developments in imaging of inflammation of the
vulnerable plaque. CURR OPIN LIPIDOL, 2008. 19(1): p. 98-100.
-
Van der Heiden, K., et al., Endothelial primary cilia in areas
of disturbed flow are at the base of atherosclerosis. ATHEROSCLEROSIS, 2008.
196(2): p. 542-550.
-
Cheng, C., et al., Large variations in absolute wall shear
stress levels within one species and between species. Atherosclerosis, 2007.
195(2): p. 225-235.
-
Goertz, D.E., et al., Subharmonic contrast intravascular
ultrasound for vasa vasorum imaging. Ultrasound Med Biol, 2007. 33(12): p.
1859-1872.
-
Helderman, F., et al., Effect of shear stress on vascular
inflammation and plaque development. Curr Opin Lipidol, 2007. 18(5): p.
527-533.
-
Susa, D., et al., Donor pre-treatment with tacrolimus reduces
transplant vasculopathy. TRANSPL INT, 2007. 20: p. 141-141.
-
Jackson, C.L., et al., Assessment of unstable atherosclerosis
in mice. Arterioscler Thromb Vasc Biol, 2007. 27(4): p. 714-720.
-
Cheng, C., et al., Shear stress-induced changes in
atherosclerotic plaque composition are modulated by chemokines. J CLIN INVEST,
2007. 117(3): p. 616-626.
-
Segers, D., et al., Gelatinolytic activity in atherosclerotic
plaques is highly localized and is associated with both macrophages and smooth
muscle cells in vivo. CIRCULATION, 2007. 115(5): p. 609-616.
-
Goertz, D.E., et al., Vasa vasorum and molecular imaging
of atherosclerotic plaques using nonlinear contrast intravascular ultrasound.
NETH HEART J, 2007. 15(2): p. 77-80.
-
Kofflard, M.J., et al., Coronary flow reserve in
hypertrophic cardiomyopathy: relation with microvascular dysfunction and
pathophysiological characteristics. Neth Heart J, 2007. 15(6): p. 209-215.
-
Cheng, C., et al., Response to letter regarding article,
"Atherosclerotic lesion size and vulnerability are determined by patterns
of fluid shear stress". CIRCULATION, 2006. 114(22): p. E615-E615.
-
Frijlink, M.E., et al., Harmonic intravascular ultrasound
imaging with a dual-frequency catheter. Ultrasound Med Biol, 2006. 32(11): p.
1649-1654.
-
Frijlink, M.E., et al., Intravascular ultrasound tissue
harmonic imaging in vivo. IEEE T ULTRASON FERR, 2006. 53(10): p. 1844-1852.
-
Goertz, D.E., et al., Contrast harmonic intravascular
ultrasound: a feasibility study for vasa vasorum imaging. Invest Radiol, 2006.
41(8): p. 631-638.
-
Cheng, C., et al., Atherosclerotic lesion size and
vulnerability are determined by patterns of fluid shear stress. CIRCULATION,
2006. 113(23): p. 2744-2753.
-
Nette, R.W., et al., Norepinephrine-induced
vasoconstriction results in decreased blood volume in dialysis patients.
NEPHROL DIAL TRANSPL, 2006. 21(5): p. 1305-1311.
-
Cheng, C., et al., Shear stress affects the intracellular
distribution of eNOS: direct demonstration by a novel in vivo technique. BLOOD,
2005. 106(12): p. 3691-3698.
-
Davies, P.F., J.A. Spaan, and R. Krams, Shear stress biology of the
endothelium. Ann Biomed Eng, 2005. 33(12): p. 1714-1718.
-
Ie, E.H., et al., Myocardial contractility does not
determine the haemodynamic response during dialysis. Nephrol Dial Transplant,
2005. 20(11): p. 2465-2471.
-
Krams, R., et al., In vivo temperature heterogeneity is
associated with plaque regions of increased MMP-9 activity. EUR HEART J, 2005.
26(20): p. 2200-2205.
-
Wentzel, J.J., et al., Geometry guided data averaging
enables the interpretation of shear stress related plaque development in human
coronary arteries. J BIOMECH, 2005. 38(7): p. 1551-1555.
-
Krams, R., et al., Effect of vessel curvature on Doppler
derived velocity profiles and fluid flow. Ultrasound Med Biol, 2005. 31(5): p.
663-671.
-
Wentzel, J.J., R. Krams, and C.J. Slager, Letter regarding article by
Korshunov and Berk, "Strain-dependent vascular remodeling: The 'Glagov
phenomenon' is genetically determined". CIRCULATION, 2005. 111(9): p.
E119-E119.
-
Schaar, J.A., et al., Three-dimensional palpography of
human coronary arteries - Ex vivo validation and in-patient evaluation. HERZ,
2005. 30(2): p. 125-133.
-
Krams, R., et al., Diastolic coronary vascular reserve: a new
index to detect changes in the coronary microcirculation in hypertrophic
cardiomyopathy. J Am Coll Cardiol, 2004. 43(4): p. 670-677.
-
Verheye, S., et al., Intravascular thermography: Immediate
functional and morphological vascular findings. Eur Heart J, 2004. 25(2): p.
158-165.