TITLE:
Association between mRNA Expression of Aromatase, 17β-HSD2, Level of TGF-β1 and Stage of Endometriosis
AUTHORS:
Ruswana Anwar, Firman F. Wirakusumah, Duddy S. Nataprawira, Ani M. Maskoen, Wiryawan Permadi, Tono Djuwantono
KEYWORDS:
Aromatase, 17βHSD2, TGFβ1, Stage Endometriosis
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.6 No.7,
June
16,
2016
ABSTRACT: Aim: To identify the correlation
between mRNA expression of aromatase, 17β-HSD2 level of TGF-β1 and stage of endometriosis. Methods: Case control study was done on 80 patients divided
by 40 endometriosis patients and 40 patients as control. mRNA expression of
aromatase, mRNA 17β-SD2, was checked using reverse-transcriptase polymerase
chain reaction (RT-PCR) and TGF-β1 serum and peritoneal fluid was checked using ELISA.
Result: Level of mRNA aromatase from ectopic and eutopic endometrium increased
significantly compared to control group (p TGF-β1
on endometriosis group was significantly higher compared to control group (p
serum level to endometriosis stage. There are
significant correlations between peritoneal fluid TGF-β1
levels to endometriosis stage.