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has been cited by the following article:

• TITLE: In Silico Molecular Interaction Studies of Suberoylanilide Hydroxamic Acid and Its Modified Compounds with Histones Deacetylase Class II Homo sapiens as Curative Measure towards Cervical Cancer

  AUTHORS: Usman Sumo Friend Tambunan, Arli Aditya Parikesit, Tirtana Prasetia, Djati Kerami

  KEYWORDS: Cervical Cancer; HPV; HDAC; SAHA; LigX; Dynamics Simulations

  JOURNAL NAME: Engineering, Vol.5 No.10B, October 31, 2013

  ABSTRACT: The threat of cervical cancer is a serious problem for the women’s health. It is already known that the cause of cervical cancer is definitely HPV (Human Papilloma Virus). The drug development is the most reasonable approach for coping with HPV infection. The development of HDACi (Histone Deacetylase inhibitor) is seen as a feasible method for curing the threat of cervical cancer. Rational drug design is our utilized pipeline for drug development. The LigX MOE-based method has been developed to investigate the molecular interaction of HDAC class IIHomo sapienswith the designed lead compound. The method has found that ligands 1c, 2a, and 2c are indeed feasible to be formulated as drug candidates.