Chia, P.L., Mitchell, P., Dobrovic, A. and John, T. (2014) Prevalence and Natural History of ALK Positive Non-Small-Cell Lung Cancer and the Clinical Impact of Targeted Therapy with ALK Inhibitors. Clinical Epidemiology, 6, 423-432.
https://doi.org/10.2147/CLEP.S69718

has been cited by the following article:

• TITLE: ALK-Rearranged Lung Adenocarcinoma Initially Presenting with Cutaneous Metastases: A Case Report

  AUTHORS: Harshitha Dudipala, Clare Townsend, Navid Alavi, Peter Everett

  KEYWORDS: ALK-Rearranged, Lung Adenocarcinoma, Cutaneous Metastases, Case Report

  JOURNAL NAME: Case Reports in Clinical Medicine, Vol.12 No.7, July 20, 2023

  ABSTRACT: Only 1% - 12% of patients with lung cancer develop cutaneous metastases. While adenocarcinoma is incredibly common, it is rare for a cutaneous manifestation of the disease to be the initial presenting complaint. Skin manifestations can be difficult to identify and can appear to be deceptively benign, leading to delays in diagnosis and treatment. ALK+ lung cancer specifically has an increased frequency of distant lymph node involvement and lymphangitic carcinomatosis relative to typical EGFR+ lung cancer. Herein we report a case of ALK-rearranged lung adenocarcinoma that initially presented as cutaneous skin metastases to the neck. Such skin lesions should be identified early, and considered as a potential manifestation of an internal malignancy. Given the poor prognosis associated with cutaneous metastases, further diagnostic tests, such as imaging or biopsy, should be done with urgency.