TITLE:
Long-Term Follow-Up of 82 Cavernous Sinus Meningiomas Treated with Radiosurgery
AUTHORS:
Mari Pascual Gallego, Jose Samblas, Jose Carlos Bustos, Jose Angel Gutierrez Diaz, Marisa Gonzalez, Kita Sallabanda
KEYWORDS:
Cavernous Sinus Meningioma, Radiosurgery, LINAC
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.5 No.11,
September
26,
2014
ABSTRACT: The cases of 82 patients with cavernous sinus meningioma (CSM)
treated with Stereotactic Radiosurgery (SRS) at our institution from 1992 to
2005 were retrospectively reviewed. The mean follow-up time was 8.38 years.
Patients’age ranged between 16 and 78 years (mean 51). There were 35
patients who had been operated before, and two of them had been treated with
fractionated radiotherapy. Twenty-three from 35 patients were surgically
intervened(65.7%)andpresented post-surgical morbidity. Only in 3 cases the
surgery was considered complete. The patients were referred for SRS treatment
due to having tumour remains or a tumour growth. The mean volume of the tumour
was 17.96 (+/?13.67) cm3.All the patients had been treated with a Linear Accelerator
(LINAC) using a high precision positioning and radiation system (SRS 2000)
University of Florida. The clinical progress of the patients was assessed using
preand post-SRS radiological imaging, post-surgical and pre-post-SRS morbidity
and mortality. Tumour volume decreased significantly with RS in 61 of 82
patients (74.4%). The tumour volume remained stable 12 patients (14.6%) and
only in 9 patients (11%) was there tumour growth after SRS. Of these, 5
required surgical intervention, and 7 of the 82 underwent SRS or another
fractionated stereotactic radiotherapy after the RS. Morbidity due to the SRS
was only seen in 14 out of the 82 patients treated with SRS, five of them
recovered completely. SRS is a high precise and effective treatment with low
morbidity, becoming more and more the option of choicesin the treatment of cavernous
sinus meningioma.