Dr. Francois X.
Claret
Department of Systems Biology, Division of Cancer Medicine
University of Texas, USA
Associate Professor
Email: fxclaret@mdanderson.org
Qualifications
1997 Postdoc., School of Medicine, University of
California
1993 Ph.D., Molecular Biology, University of
Lausanne
Publications (Selected)
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Vu TT, Sliwkowski MX, Claret FX. Personalized
drug combinations to overcome trastuzumab resistance in HER2-positive breast
cancer. Biochimica et Biophysica Acta - Reviews on Cancer. In Press.
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Astaves V, Lekakis L, Drakos I, Leventaki V,
Jones D, Feretzaki M, Liakou C, Korapati A, Horie R, Panayiotidis P, Gorgoulis
V, Patsouris E, Medeiros JL, Claret FX, Rassidakis G. The oncogenic JunB/CD30
axis contributes to cell cycle deregulation in ALK+ anaplastic large cell
lymphoma. British Journal of Hematology. In Press.
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Zhou F, Meng S, Song H, Claret FX.. Dickkopf-1
is a key regulator of myeloma bone disease: Opportunities and challenges for
therapeutic intervention. Blood Reviews 27(6):261–267, 9/2013. PMID: 24054128.
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Zhou F, Shen Q, Claret FX.. Novel roles of
reactive oxygen species in the pathogenesis of acute myeloid leukemia. Journal
of Leukocyte Biology 94(3):423-9, 9/2013. PMID: 23715741.
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Pan Y, Wang M, Bu X, Zuo Y, Wang S, Wang D, Liu
Q, Xu T, Wang C, Claret FX, Yang H. Curcumin analogue T83 exhibits potent
antitumor activity and induces radiosensitivity through inactivation of Jab1 in
nasopharyngeal carcinoma. BMC cancer 13(1):323, 7/2013. PMID: 23815987.
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Pan Y, Zhang Q, Atsaves V, Yang H, Claret FX.
Suppression of Jab1/CSN5 induces radio- and chemo-sensitivity in nasopharyngeal
carcinoma through changes to the DNA damage and repair pathways. Oncogene
32(22):2756-66, 5/2013. PMCID: PMC3566273.
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Echalier A*, Pan Y*, Birol M, Tavernier N,
Pintard L, Hoh F, Ebel C, Galophe N, Claret FX, Dumas C. (*) Equal
contribution. Insights into the regulation of the human Cop9 signalosome
catalytic subunit, CSN5/Jab1. Proceedings of the National Academy of Sciences U
S A (PNAS) 110(4):1273-8, 1/2013. PMID: 23288897.
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Pan Y, Zhou F, Zhang R, Claret FX. Stat3
inhibitor Stattic exhibits potent antitumor activity and induces chemo- and
radio-sensitivity in nasopharyngeal carcinoma. PLOS ONE 8(1):e54565,
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0054565,
January 29, 2013. PMCID: PMCPMC3558509.
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Vu T and Claret FX. Trastuzumab: updated
mechanisms of action and resistance in breast cancer. Frontiers in Cancer
Molecular Targets and Therapeutics. 2(62), 6/2012. PMCID: PMC3376449.
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Pan Y, Zhang Q, Tian L, Wang X, Fan X, Zhang H,
Claret FX, Yang H. Jab1/CSN5 negatively regulates p27 and plays a role in the
pathogenesis of nasopharyngeal carcinoma. Cancer Research 72(7):1890-1900,
4/2012. PMCID: PMC3460549.
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Zhang Q, Claret FX. Phosphatases: the new
brakes for cancer development? Enzyme Research 2012(659649), 2012. e-Pub
10/2011. PMCID: PMC3206369.
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Shackleford TJ, Zhang Q, Tian L, Vu TT,
Korapati AL, Baumgartner A, Le XF, Liao WS, Claret FX.. STAT3 and
CCAAT/Enhancer Binding Protein beta (C/EBP-β) regulate Jab1/CSN5 expression in
mammary carcinoma cells. Breast Cancer Research 13(3):R65, 6/2011. PMCID:
PMC3218954.
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Drakos E, Rassidakis G, Schlette E, Li J, Singh
RJ, Vega F, Claret FX, Ford J, Medeiros LJ.. Activation of p53 Pathway by MDM2
Inhibitor Nutlin-3a Overcomes BCL2 Overexpression in a Preclinical Model of
Diffuse Large B-cell Lymphoma Associated with t(14;18)(q32;q21). Leukemia
(Nature Publishing Group) 5(25):856-867, 2011. PMCID: PMC3094765.
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Drakos E, Leventaki V, Atsaves V, Schlette EJ,
Lin P, Vega F, Claret FX, Medeiros JL, Rassidakis GZ.. Expression of Serine
194-phosphorylated FADD strongly correlates with proliferation in B-cell
Non-Hodgkin lymphomas. Human Pathology 42(8):1117-24, 2011. PMID: 21315423.
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Le XF, Mao W, He G, Claret FX, Xia W, Ahmed AA,
Hung MC, Siddik ZH, Bast RC Jr.. The Role of p27Kip1 in Dasatinib-Enhanced
Paclitaxel Cytotoxicity in Human Ovarian Cancer Cells. Journal of the National
Cancer Institute (JNCI) 103(18):1403-22, 2011. PMCID: PMC3176777.
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Tian L, Peng G, Parant JM, Leventaki V, Drakos
I, Zhang Q, Parker-Thornburg J, Shackleford T, Dai H, Lin, S-Y. Lozano G, Rassidakis,
GZ, Claret FX.. Essential Roles of Jab1 in Cell Survival, Spontaneous DNA
Damage, and DNA Repair. Oncogene (Nature Publishing Group) 29(46):6125-6137,
2010. PMCID: PMC3495558.
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Shackleford T, Claret FX. JAB1: a new player in
cell cycle control and cancer. Cell Division 5(1):1-14, 2010. PMCID:
PMC2976740.
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Vivas-Mejia P, Benito JM, Fernandez A, Han HD,
Mangala L, Rodriguez-Aguayo C, Chavez-Reyes A, Lin YG, Carey MS, Nick AM, Stone
RL, Kim HS, Claret FX, Bornmann W, Hennessy BT, Sanguino A, Peng Z, Sood AK,
Lopez-Berestein G. JNK-1 Inhibition Leads to Antitumor Activity in Ovarian
Cancer. Clinical Cancer Research 1(16):184-94, 2010. PMID: 20028751.
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Shin S, Asano T, Yao Y, Krishnan K, Korc M,
Sabapathy K, Menter DG, Claret FX, Abbruzzese JL and Reddy SA. Activator
Protein-1 has an essential role in pancreatic cancer cells and is regulated by
a novel AKT-mediated mechanism. Molecular Cancer Research 7(5):745-54, 2009.
PMID: 19435822.
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Estrella VC, Eder AM, Liu S, Pustilnik TB,
Tabassam FH, Claret FX, Gallick GE, Mills GB, Wiener JR. Lysophosphatidic acid
induction of urokinase plasminogen activator secretion requires activation of
the p38MAPK pathway. International Journal of Oncology 31(2):441-9, 2007. PMID:
17611702.
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Leventaki V, Drakos E, Medeiros LJ, Lim MS,
Elenitoba-Johnson KS, Claret FX and Rassidakis GZ.. NPM-ALK oncogenic kinase
promotes cell cycle progression through activation of JNK/c-Jun signalling in
anaplastic large cell lymphoma. Blood 110(5):6589-89, 2007. PMID: 17416736.
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Vega F, Medeiros JF, Atwell C, Cho-Vega JH,
Tian L, Claret FX, Rassidakis GZ. Activation of mammalian target of rapamycin
signaling pathway contributes to tumor cell survival in anaplastic lymphoma
kinase-positive anaplastic large cell lymphoma. Cancer Research 66(13):6589-97,
2006. PMID: 16818631.
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Kim HJ, Chakravarti N, Oridate N, Choe C,
Claret FX, Lotan R. N-(4-hydroxyphenyl)retinamide-induced apoptosis triggered
by reactive oxygen species is mediated by activation of MAPKs in head and neck
squamous carcinoma cells. Oncogene 25(19):2785-94, 2006. PMCID: PMC1458365.
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Kouvaraki MA, Korapati AL, Rassidakis GZ, Tian
L, Zhang Q, Chiao P, Ho L, Evans DB, Claret FX. Potential Role of Jun
Activation Domain-Binding Protein 1 as a Negative Regulator of p27kip1 in
Pancreatic Adenocarcinoma. Cancer Research 66(17):8581-9, 2006. PMCID:
PMC1780177.
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Zhang Q, Tian L, Mansouri A, Korapati AL,
Johnson TJ, Claret FX. Inducible expression of a degradation-resistant form of
p27Kip1 causes growth arrest and apoptosis in breast cancer cells. FEBS Letters
579(18):3932-40, 2005. PMCID: PMC1366489.
Profile Details
http://faculty.mdanderson.org/Francois-Xavier_Claret/