Dr. Subha Sen

University of California, USA

Email: subhasen@mednet.ucla.edu

Qualifications

2012-2017 Post-doctoral Fellowship, Beckman Research Institute, City of Hope, USA

2005-2011 Ph.D., Indian institute of chemical biology, India

2002-2005 M.S., University of Calcutta, India

Publications (Selected)

1. Harry Pickering, Subha Sen, Janice Arakawa-hoyt, Kenichi Ishiyama, David Gjertson, Maura Rossetti, Lewis L Lanier, Elaine F. Reed. Dynamic Changes in Natural Killer Cell Subsets in Cytomegalovirus Infection in Kidney Transplant Recipients- JCI insight (2021).
2. Jing Zhang, Zhiheng He, Subha Sen, Fei Wang, Qiang Zhang and Zuoming Sun. TCF-1 Inhibits IL-17 Gene Expression To Restrain Th17 Immunity in a Stage-Specific Manner. The Journal of Immunology (2018).
3. Subha Sen, Shubhomoy Ghosh, Kenneth J Dery, Zhiheng He, Lu Yang, Jing Zhang and Zuoming Sun. Critical role of PRMT1 in the regulation of counteracting activities of STAT3 and STAT5 during Th17 differentiation. The Journal of Immunology (2018).
4. Subha Sen, Fei Wang, Jing Zhang, Zhiheng He, Jian Ma, Yousang Gwack and Zuoming Sun. SRC1 promotes Th17 differentiation by overriding Foxp3 suppression to stimulate RORγt activity in a PKC-θ dependent manner. PNAS (2017).
5. Zhiheng He, Fei Wang, Jing Zhang, Subha Sen, Qihua Pang, Shengwei Luo, Yousang Gwack andZuoming Sun. Regulation of Th17 Differentiation by IKKα-Dependent and -Independent Phosphorylation of RORγt. The Journal of Immunology, (2017).
6. Zhiheng He, Jian Ma, Fei Wang, Ruiqing Wang, Zhaofeng Huang, Jing Zhang, Subha Sen, Ellen V Rothenberg and Zuoming Sun. A two-amino-acid substitution in the transcription factor RORγt disrupts its function in TH17 differentiation but not in thymocyte development. Nature Immunology (2017).
7. Zhiheng He, Fei Wang, Jian Ma, Subha Sen, Jing Zhang, Yousang Gwack, Yu Zhou and Zuoming Sun. Ubiquitination of RORγt at Lysine 446 Limits Th17 Differentiation by Controlling Co-activator Recruitment. The Journal of Immunology, (2016).
8. Subha Sen, Koushik Roy, Sandip Mukherjee, Rupkatha Mukhopadhyay and Syamal Roy. Cholesterol Dependent Regulation of IFNγR Subunit Interaction Determines IFNγ Signaling Efficacy in Leishmania donovani Infected Macrophages. PLoS Pathog. 2011 Sep; 7(9):e1002229.
9. Suniti Bhaumik, Rajatava Basu, Subha Sen, Kshudiram Naskar and Syamal Roy. KMP-11 DNA immunization significantly protects against L. donovani infection but requires exogenous IL-12 as an adjuvant for comparable protection against L. major. Vaccine. 2009 Feb 25; 27(9):1306-16.
10. Subha Banerjee, June Ghosh, Subha Sen, Rajan Guha, Ranjan Dhar, Moumita Ghosh, Sanchita Datta, Bikramjit Raychaudhury, Kshudiram Naskar, Arun Kumar Haldar, C. S. Lal, K. Pandey, V. N. R. Das, Pradeep Das, and Syamal Roy. Designing therapies against experimental visceral leishmaniasis by modulating the membrane fluidity of antigen-presenting cells. Infect Immun. 2009 Jun; 77(6):2330-42.
11. Richard Ahn, Joanna Schaenman, Zach Qian, Harry Pickering, Victoria Groysberg, Maura Rossetti, Megan Llamas, Alexander Hoffmann, David Gjertson, Mario Deng, Suphamai Bunnapradist, Elaine F. Reed, CMV Systems Immunobiology Group (Richard Ahn, Janice Arakawa-Hoyt, Patrick Boada, Jenny Brook, Suphamai Bunnapradist, Izabella Damm, Nakul Datta, Mario Deng, Don J. Diamond, Tin Doung, Janette Gadzhyan, David Elashoff, David Gjertson, Victoria Groysberg, Alexander Hoffman, Kenichi Ishiyama, Maggie Kerwin, Lewis L. Lanier, Megan Llamas, Erik Lum, Tariq Mukatash, Harry Pickering, Zach Qian, Michelle Ramirez, Elaine F. Reed, Rodney Rodgers, , Maura Rossetti, Dimitri Rychov, Minnie M. Sarwal, Joanna Schaenman, Subha Sen, Tara Sigdel, Danielle Sim, Marina Sirota, Swastika Sur, Praveena Velperusiva, Otto Yang). Acute and Chronic Changes in Gene Expression after CMV DNAemia in Kidney Transplant Recipients (Frontiers in Immunology, 2021).
12. Kenichi Ishiyama, Janice Arakawa-Hoyt, Oscar A. Aguilar, Izabella Damm, Parhom Towfighi, Sigdel Tara, Stanley Tamaki, Joel Babdor, Matt Spitzer, Elaine F. Reed, Minnie M. Sarwal, Lewis L. Lanier, The CMV Systems Immunobiology Group (Richard Ahn, Janice Arakawa-Hoyt, Patrick Boada, Jenny Brook, Suphamai Bunnapradist, Izabella Damm, Nakul Datta, Mario Deng, Don J. Diamond, Tin Doung, Janette Gadzhyan, David Elashoff, David Gjertson, Victoria Groysberg, Alexander Hoffman, Kenichi Ishiyama, Maggie Kerwin, Lewis L. Lanier, Megan Llamas, Erik Lum, Tariq Mukatash, Harry Pickering, Zach Qian, Michelle Ramirez, Elaine F. Reed, Rodney Rodgers, , Maura Rossetti, Dimitri Rychov, Minnie M. Sarwal, Joanna Schaenman, Subha Sen, Tara Sigdel, Danielle Sim, Marina Sirota, Swastika Sur, Praveena Velperusiva, Otto Yang). Mass cytometry reveals single-cell kinetics of cytotoxic lymphocyte evolution in CMV-infected renal transplant patients (in Press, PNAS).