TITLE:
Tissue Engineering: From Bench to Bed Side Exemples of Applications
AUTHORS:
J-F. Stoltz, C. Huselstein, D. Bensoussan, N. de Isla, V. Decot
KEYWORDS:
Tissue Engineering; Stem Cells; Scaffolds
JOURNAL NAME:
Engineering,
Vol.4 No.10B,
January
17,
2013
ABSTRACT:
Tissue engineering is an emerging multidisciplinary field involving
surgery medicine, biology, chemistry, mechanics and engineering to improve the health and quality of life by restoring, maintaining or
enhancing tissue and organ function[6;11]. The principle is simple:
cells are collected and introduced -with or without modification of their
biological properties- into an environment in which physico-chemical and
mechanical parameters are kept stable. When they reach maturity, the biotissue
or cells can be grafted. The main parameters are: cells, scaffold, biological
molecules and mechanical forces. A combination of these parameters can promote
cellular differentiation and proliferation. But it should be emphasized that at
this time, signalling pathways and the rationale behind the physiological
design remain to be elucidated. Among the main medium-term
clinical applications are cardiac insufficiency, atherosclerosis,
osteoarthritis, diabetes, liver diseases, bladder, and skin. In this paper the
examples of cartilage and vascular engineering will be examined.