TITLE:
A Case Report of Scrub Typhus: Secondary Acute Arrest of Hemopoiesis with Multiple Organ Dysfunction Syndromes
AUTHORS:
Guancheng Song, Ying Song, Yanfang Zhang, Xi Huang, Jianchuan Deng
KEYWORDS:
Scrub Typhus, Orientia tsutsugamushi, Acute Arrest of Hemopoiesis, Multiple Organ Dysfunction Syndrome
JOURNAL NAME:
Open Journal of Blood Diseases,
Vol.12 No.3,
September
2,
2022
ABSTRACT: Scrub typhus is a zoonotic disease caused by Orientia tsutsugamushi (O. tsutsugamushi) in which humans are accidental hosts. Acute arrest of
hemopoiesis (AAH) always
manifests in pancytopenia and with supportive treatment or inducement removal,
the AAH patients would show significant improvement in blood routine for about a week. As a rapidly progressive and
potentially life-threatening organ function disorder syndrome, multiple organ
dysfunction syndrome (MODS) is often induced by many factors including infection, illness and injury. We received a
rare case of scrub typhus rapidly presenting with AAH and MODS 2 weeks ago. The
clinical data of a 32-year-old female with O. tsutsugamushi-induced AAH
and MODS was summarized retrospectively and analyzed with a literature review.
In this case, we selected tigecycline and moxifloxacin as treatment regimens for scrub typhus. When the potential infection was controlled, her pancytopenia and hepatic function rapidly improved in a few days.