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https://doi.org/10.4149/neo_2018_161128N594

has been cited by the following article:

• TITLE: Association Study of Thyroid Papillary Carcinoma with Depression and BDNF Expression

  AUTHORS: Hongbiao Lin, Kunmei Wu, Xinguang Zhang, Xingjie Huang, Chongcai Wu, Haixiang Cai

  KEYWORDS: Papillary Thyroid Carcinoma, Depressive Disorder, Brain-Derived Neurotrophic Factor, Polymerase Chain Reaction

  JOURNAL NAME: Journal of Cancer Therapy, Vol.13 No.7, July 15, 2022

  ABSTRACT: Objective: To analyze the correlation between Val66Met gene of brain-derived neurotrophic factor (BDNF) and papillary thyroid carcinoma (PTC) complicated with depression. To evaluate the clinical value of papillary thyroid carcinoma. Methods: Self-rating Anxiety Scale (SAS) and Self-rating Depression Scale (SDS) were used to assess the correlation of BDNF in the blood of patients with depressive disorder of thyroid papillary carcinoma using polymerase chain reaction PCR. The relationship between BDNF gene polymorphism and the incidence of thyroid papillary carcinoma was analyzed, and the susceptibility factors of thyroid papillary carcinoma complicated with depression were explored. Results: Compared with normal control group, T3 and T4 of PTC in non-depressed group were decreased, while TSH and TPOAb were increased (P Conclusion: There is a significant difference between PTC with depression and PTC without depression, which is related to SNP rs6265 of BDNF gene. AG and GG are both risk sites of PTC with depression, and GG type is more prone to PTC with depression.