TITLE:
Monte Carlo Analysis of Different Administration Regiments for Isavuconazole against Candida spp. and Aspergillus spp.
AUTHORS:
Jiuli Hu, Chanchan Hu, Xiaoqin Zhu
KEYWORDS:
Monte Carlo Simulation (MSC), Isavuconazole, Candida spp., Aspergillus spp.
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.12 No.12,
December
24,
2021
ABSTRACT: In our study, we aimed to
optimize the dosage regimen of Isavuconazole against Candida spp. and Aspergillus spp. by Monte
Carlo simulation (MSC). Pharmacokinetic parameters and microbiological data of
Isavuconazole were collected. Then we used MSC to simulate 10,000 patients
analyzed by Crystal Ball to calculate probability of target attainment (PTA)
and cumulative fraction of response (CFR). With dosages of 100 mg, 200 mg, and
400 mg in oral group and dosages of 100 mg, and
200 mg in intravenous administration, all have different degrees of
antifungal effect. But when the dosage regimen was 50 mg IV,
the therapeutic effect of Isavuconazole against Aspergillus spp. and Candida
spp. were not good.