TITLE:
Evaluation of Lipid Profile in Obese and Non-Obese Hypertensive Adult Patients Attended in Medicine Department of a Medical College Hospital of Bangladesh
AUTHORS:
Md Reaz Uddin Chowdhury, Kazi Shanzida Akter, Sahedul Islam Bhuiyan, Mainuddin Sohel, Mahbub Majumder, Arif Mohammad Sohan, Mahfuzur Rahman, Muhammad Anwarul Kabir, Zaman Ahmed
KEYWORDS:
Lipid Profile, Dyslipidaemia, Obese, Non-Obese, Hypertension
JOURNAL NAME:
World Journal of Cardiovascular Diseases,
Vol.10 No.8,
August
17,
2020
ABSTRACT:
Background: By the dawn of this modern
era of science, the prime challenge of physician is cardiovascular disease
(CVD). The most important modifiable risk factors of CVDs are unhealthy diet,
physical inactivity and tobacco use. The effects of unhealthy diet and physical
inactivity include abnormal blood lipid, obesity and hypertension. We tried to
evaluate and correlate the pattern of lipid profile in obese and non-obese
hypertensive patients. Objectives: This study was conducted at medicine
department of Cumilla Medical College Hospital. The principal aim was to
evaluate the lipid profile in obese and non-obese adult hypertensive patients. Methodology: During this cross sectional analytical study, a total of 100 adult hypertensive
patients were taken by purposive sampling. Among them 50 (group 1) patients
were taken those were obese and 50 (group 2) patients taken
those were non-obese according to BMI measurement on operational definition.
Diagnosis of hypertension would be established with the help of ambulatory BP
measurements two occasions few minutes apart. The staging of hypertension was
done according to JNC7 Criteria. Morning blood samples were taken after 8 - 12 hours of fasting
and lipid profiles were done on authentic laboratories. The laboratory values
were interpreted according to the operational definition of dyslipidaemia. The
ethical research and review committee approved the study protocol and signed
informed consent was obtained from the participants. The statistics was
analyzed using the IBM SPSS software of version 19.0. Statistical significance
was set at p Results: Among the two groups, there were 56 (56%)
males and 44 (44%) females. The mean age of group 1 (46.10 ± 11.09) was
compared to that of group 2 (45.5 ± 10.6). Lipid profile abnormalities were significantly
higher in the stage 2 hypertension (59.62%) and stage 3
hypertension (66.66%), higher in class 2 obese (100%) and class 3
obese subjects (100%), female hypertensive patients had significantly higher
BMI than their male counterparts (27.24 ± 3.63 kg/m2 versus
29.29 ± 3.99 kg/m2), lipid profiles were higher in the female than male hypertensive patients
(63.33% vs 55.35%) but only TC was statistically significant (4.45 ± 1.19 mmol/l versus 4.86 ± 1.29 mmol/l, p (76%) of the obese
hypertensive patients had dyslipidaemia whereas 21 (42%) of non-obese
hypertensive patients had dyslipidaemia. In multivariate regression, TG was
significantly and directly associated with BMI of subjects. Dyslipidaemia was
more prevalent in the age group 30 - 59 of adult
hypertensive patients. It showed that obese hypertensive patients had
significantly higher SBP (p (p mmol/l versus 4.15 ± 0.57 mmol/l, t = -9.70, p
mmol/l versus 2.10 ± 0.45 mmol/l, t = -5.37, p
mmol/l versus 2.44 ± 0.53 mmol/l, t = -9.11, p
mmol/l versus 1.24 ± 0.57 mmol/l, t = -0.25, p
= 0.08)...