Hyvonen, Z., Ronkko, S., Toppinen, M.-R., Jaaskelainen, I., Plotniece, A. and Urtti, A. (2004) Dioleoylphosphati Dylethanolamini and PEG-lipid conjugates modify DNA delivery mediated by 1,4-dihydropyridine amphiphiles. Journal of Controlled Release, 99, 177-190. doi:10.1016/j.jconrel.2004.06.019

has been cited by the following article:

• TITLE: 1,4-DHP-lipid parameters and rod like micellae

  AUTHORS: Inta Liepina, Cezary Czaplewski, Adam Liwo, Gunars Duburs

  KEYWORDS: Lipid; Gene Transfection; Rod-Like Structure; Worm-Like Micellae; Tubular Micellae; Molecular Dynamics

  JOURNAL NAME: Journal of Biophysical Chemistry, Vol.2 No.4, November 9, 2011

  ABSTRACT: The cationic amphiphilic lipid type compound 1,1’-{[3,5-bis(dodecyloxycarbonyl)-4-phenyl-1,4- dihydropyridin-2,6-diyl]dimethylene} bispyridinium dibromide (1,4-DHP lipid) (charge +2), is a gene transfection agent. The electronic structure of 1,4-DHP lipid molecule was investigated by ab initio quantum mechanics, the charges were derived, and the supramolecular structure formed by 1,4-DHP lipid molecules in water was investigated by means of molecular dynamics simulation, f99 force field, version AMBER 8.0. During the molecular dynamics simulations of 10 ns of MD 1,4-DHP lipid formed a worm-like micellae, which was preserved during the time course of 300 ns of MD simulations. Result was confirmed with the electron microscopy showing extended, rod-like structures as one of the 1,4-DHP lipid supramolecular structures, which are expected to be formed at high 1,4-DHP lipid concentrations.