TITLE:
Physicochemical Properties and Control Release of Aloe Vera (Aloe barbadensis Miller) Bioactive Loaded Poly (Lactic Co-Glycolide Acid) Synthesized Nanoparticles
AUTHORS:
Lamin S. Kassama, Jawadul Misir
KEYWORDS:
Nanoencapsulation, PLGA, Aloe Vera Gel, Size Distribution, Time Release Kinetics & Antioxidant
JOURNAL NAME:
Advances in Chemical Engineering and Science,
Vol.7 No.4,
August
15,
2017
ABSTRACT: Nano-encapsulation is a platform which offers a promising application for
control release and the delivery of drugs in pharmaceuticals and antioxidant/
antimicrobial in food systems. Poly (lactic-co-glycolide acid) (PLGA) is a
biodegradable and biocompatible co-polymer of lactic acid and glycolic acid
which is used for synthesizing food based polymeric nanoparticles (NP). The
aim of this study was to evaluate the morphological and physicochemical properties
and the controlled release of bioactive components derived from Aloe vera
gel loaded PLGA NP. The results shows the mean hydrodynamic diameter of
the unloaded NP is 103 nm which is significantly (p p > 0.05) inhibition of the antioxidant potential was observed with
loaded NP. The entrapment efficiency for the FDG synthesized was 87%, and
the burst effect was observed after 4 h as a result of the encapsulation effect. The
release kinetics of bioactive is govern by the combination of mass diffusion and
capillary action.