Article citationsMore>>
Cui, L., Jia, J., Ma, C.F., Li, S.Y., Wang, Y.P., Guo, X.M., Li, Q., Yu, H.B., Liu, W.H. and Gao, L.B. (2012) IL-13 Polymorphisms Contribute to the Risk of Asthma: A Meta-Analysis. Clinical Biochemistry, 45, 285-288.
http://dx.doi.org/10.1016/j.clinbiochem.2011.12.012
has been cited by the following article:
-
TITLE:
Identifying the Roles of Interleukin-13 in Childhood Asthma
AUTHORS:
Kamleshun Ramphul
KEYWORDS:
Asthma, Interleukin 13, Children
JOURNAL NAME:
Open Access Library Journal,
Vol.1 No.3,
June
18,
2014
ABSTRACT: Asthma is a chronic inflammatory disease of the airways manifested by reversible airflow obstruction and airway hyperresponsiveness. While recent research has mapped several genes as possible factors predisposing to asthma, interleukin-13 remains one of the most commonly found genes in various populations. IL-13 is a pleiotropic TH2 cytokine which has been linked to cause an increase in goblet cell differentiation, activation of fibroblasts, elevation of bronchial hyperresponsiveness and switching of B cell antibody from IgM to IgE. The aim of this review is to study and identify the three main single-nucleotide polymorphisms of IL-13 (IL13 R130Q, IL-13Rα1 and IL-13 A2044G) that have been linked to asthma in children, and to understand their respective roles in the pathogenesis of this disease.
Related Articles:
-
Pavas Goswami, Manoj Kumar Shukla
-
Heqiu Ruan, Linlin Zhan, Zihe Wang, Mengjuan Xia, Zhichao Ma, Shengmiao Fu, Xinping Chen
-
Lixin Xia, Fei Yang
-
Dongjun Dai, Yunliang Wang, Lingyan Wang, Jinfeng Li, Hanlin Zhou, Qingqing Ma, Xingyu Zhou, Jun Pan, Guanghui Pan, Cheng Chen, Limin Xu, Ping Ru, Hui Wang, Shengqian Zhu, Yuelong Lv, Leiting Xu, Meng Ye, Shiwei Duan
-
Krystal Castle White, Angie K. McDonald, David M. Compton