TITLE:
Three New Compounds Derived from Nitrofurantoin: X-Ray Structures and Hirshfeld Surface Analyses
AUTHORS:
Hao Wang, Hongping Xiao, Na Liu, Bo Zhang, Qian Shi
KEYWORDS:
Nitrofurantoin Co-Crystals, Intermolecular Interactions, X-Ray Structures, Hirshfeld Surface
JOURNAL NAME:
Open Journal of Inorganic Chemistry,
Vol.5 No.3,
July
24,
2015
ABSTRACT: The polymorphism of nitrofurantoin (NF), 1), the cocrystals of NF:2,2’-bipyridyl = 2:1, 2) and NF: 1,10-phenanthroline = 1:1, 3) have been prepared and characterized. The crystal structure analyses show that there are various weak forces among the molecules, such as C/N-H···O, N-H···N hydrogen bond interactions and π···π/lone pair stacking interactions, which play a key role in the assembly of supramolecular networks. A thorough analysis of Hirshfeld surfaces and fingerprint plots facilitates a comparison of intermolecular interactions in 1 - 3, which are crucial in building supramolecular architectures.