TITLE:
Update on Healthcare-Associated Blood Stream Infections in Febrile Neutropenic Pediatric Oncology Patients
AUTHORS:
Hadir A. El-Mahallawy, Safaa Shawky Hassan, Mohamed El-Wakil, Manar M. Moneer, Lobna Shalaby
KEYWORDS:
Blood Stream Infections (BSI), Febrile Neutropenia (FN), Multidrug Resistant Organism (MDRO)
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.6 No.6,
June
9,
2015
ABSTRACT: Background: Continuous surveillance of
pattern of blood stream infection is necessary in febrile neutropenia
especially with the recent escalating trend in the management of pediatric
cancer patients towards intensified regimens and with the increase in
infections caused by resistant organisms limiting the choice of antibiotics.
Aim: Monitoring if a change has occurred in pattern of blood stream infections
(BSI) in febrile neutropenic (FN) pediatric cancer patients. Methods:
Surveillance of FN episodes with positive BSI was prospectively monitored and
compared to a previous surveillance in the same pediatric oncology unit.
Results: A total of 232 BSI positive episodes were documented in 192 patients
during a 6 months period. The results of recent surveillance analysis showed an
increase in intensified regimens of chemotherapy, antimicrobial resistance, and
prolonged duration of episodes when compared to previous surveillance, with a p
value of