TITLE:
Endometrial Carcinogenesis and Molecular Signaling Pathways
AUTHORS:
Xianyong Ma, Charles X. Ma, Jianghui Wang
KEYWORDS:
Signaling Pathway, Endometrial Cancer (EC), Carcinogenesis
JOURNAL NAME:
American Journal of Molecular Biology,
Vol.4 No.3,
July
16,
2014
ABSTRACT:
The Endometrial Cancer (EC) is the most common gynecologic malignancy
that starts in the endometrium of women. Carcinogenesis of EC is associated
with several critical regulatory molecules, which involve in different
signaling pathways. A number of signaling pathways have been identified to be
involved in the multiple-step development of EC, including PI3K/AKT/mTOR
signaling pathway, WNT/β-catenin
signal transduction cascades (including APC/β-catenin pathway), MAPK/ERK pathway, VEGF/VEGFR ligand
receptor signaling pathway, ErbB signaling pathway, P53/P21 and P16INK4a/pRB
signaling pathways. This review mainly focuses on the molecular signaling pathways relevant to human endometrial cancer and
discusses those critical capabilities of transforming endometrial cells,
including evading apoptosis; enhancing cell proliferation; blocking differentiation;
and inducing angiogenesis.