TITLE:
Highly-Efficient Conversion of Primary Amides to Nitriles Using Indium(III) Triflate as the Catalyst
AUTHORS:
Tomoko Mineno, Mamika Shinada, Kazuki Watanabe, Hitoshi Yoshimitsu, Hiroyuki Miyashita, Hisao Kansui
KEYWORDS:
Indium(III) Triflate; Primary Amides; Nitriles
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.4 No.1,
February
28,
2014
ABSTRACT: Indium(III) triflate, a trivalent indium reagent, was shown to be a highly-efficient catalyst for the conversion of primary amides to the corresponding nitriles. The successful reactions required 5 mol% of indium(III) triflate, and toluene was proved to be the most suitable solvent. Various amides were subjected to this method, and each produced the corresponding nitriles in excellent yields.