TITLE:
Smoking and Pancreatic Disease
AUTHORS:
Mouad Edderkaoui, Edwin Thrower
KEYWORDS:
Smoking; Pancreatitis; Pancreatic Cancer
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.4 No.10A,
November
28,
2013
ABSTRACT:
Smoking is a major risk factor for chronic pancreatitis and pancreatic cancer. However, the mechanisms through which it causes the diseases remain unknown. In the present manuscript we reviewed the latest knowledge gained on the effect of cigarette smoke and smoking compounds on cell signaling pathways mediating both diseases. We also reviewed the effect of smoking on the pancreatic cell microenvironment including inflammatory cells and stellate cells.