Prof. Manijeh Pasdar
University of Alberta, Canada
Email: mpasdar@ualberta.ca
Qualifications
1984 Ph.D., University of Illinois, Genetics
1974 M.Sc., Pahlavi University,
Animal Breeding
1971 B.Sc., Pahlavi University,
Animal Science
Publications (selected)
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Aktary Z, Pasdar M. Plakoglobin
represses SATB1 expression and decreases in vitro proliferation, migration and
invasion. Plos One, 8(11):e78388.
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Tang Y, Mackey J, Lai R, Ghosh S,
Santos C, Graham K, Damaraju S, Pasdar M, Li L. Quantitative proteomic analysis
of HER2 normal and overexpressing MCF-7 breast cancer cells revealed proteomic
changes accompanied with HER2 gene amplification. J Proteomics. 2013 Jul
11;91C:200-209.
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Aktary Z, Kulak S, Mackey JR, Jahroudi
N., Pasdar M. Plakoglobin interacts with the transcription factor p53 and
regulates the expression of the tumor suppressor 14-3-3s. J Cell Sci. 2013 Jul 15;126(Pt
14):3031-42.
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Lam L, Aktary Z, Bishay M, Werkman C,
Kuo C-Y, Heacock M, Srivastava N, Mackey JR and Pasdar M. Regulation of
subcellular distribution and oncogenic potential of nucleophosmin by
plakoglobin. Oncogenesis 1: e4; doi:10.1038/oncsis.2012.4.
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Aktary Z, Pasdar M. Plakoglobin: Role
in Tumorigenesis and Metastasis. Invited Review, Int J Cell Biol.
2012;2012:189521.
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Aktary Z, Chapman KA, Lam L, Ji C, Lo
A, Cook L, Graham K, Mackey J, Li L, Pasdar M. Plakoglobin interacts
with, regulates the expression and increases the protein levels of
non-metastatic protein 23 (Nm23). Oncogene, 2010;29:2118-29- Featured in MDLinx
on Jan 28, 2010.
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Asgarian N, Hu X, Aktary Z, Chapman
KA, Lam L, Chibbar R, Mackey J, Greiner R, Pasdar M. Learning to predict
relapse in invasive ductal carcinomas based on the subcellular localization
of junctional proteins. Breast Cancer Res Treat. 2010;121:527-38.
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Lam L, Hu X, Aktary Z, Andrews DW,
Pasdar M. Tamoxifen and ICI 182,780 increase Bcl-2 levels and inhibit growth of
breast carcinoma cells by modulating PI3K/AKT, ERK and IGF-1R pathways independent
of ERa. Breast Cancer Research
and Treatment. Breast Cancer Research and Treatment, 2009; 118: 605-621.
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Li L, Chapman K, Hu X, Wong A, Pasdar
M. Modulation of oncogenic potential of b-catenin by subcellular distribution
of plakoglobin. Molecular Carcinogenesis 2007;46(10):824-38.
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Ji C, Li L, Gebre M, Pasdar M, Li L
Identification and quantification of differentially expressed proteins in
E-cadherin deficient SCC9 cells and SCC9 transfectants expressing E-cadherin by
dimethyl isotope labeling, LC-MALDI MS and MS/MS. J Proteome Res. 2005;4(4):1419-26.
Erratum in: J Proteome Res. 2005;4(5):1872.
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Pla P, Alberti C, Solov'eva O, Pasdar
M, Kunisada T, Larue L. Ednrb2 orients cell migration towards the dorsolateral
neural crest pathway and promotes melanocyte differentiation. Pigment Cell Res.
2005;18(3):181-7.
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Li L, Backer J, Wong AS, Schwanke EL,
Stewart BG, Pasdar M. Bcl-2 expression decreases cadherin-mediated cell-cell
adhesion. J Cell Sci. 2003 15;116(Pt 18):3687-700.
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Hakimelahi GH, Shia KS, Pasdar M,
Hakimelahi S, Khalafi-Nezhad A, Soltani MN, Mei NW, Mei HC, Saboury AA,
Rezaei-Tavirani M, Moosavi-Movahedi AA. Design, synthesis, and biological
evaluation of a cephalosporin-monohydroguaiaretic acid prodrug activated by a
monoclonal antibody-beta-lactamase conjugate. Bioorg Med Chem. 2002;10(9):2927-32.
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Gilchrist AJ, Meuser R, Turchinsky J,
Shaw AR, Pasdar M, Dixon WT. Cell adhesion-mediated transformation of a human
SCLC cell line is associated with the development of a normal phenotype. Exp
Cell Res. 2002;276(1):63-78.
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Rahn JJ, Dabbagh L, Pasdar M, Hugh JC.
The importance of MUC1 cellular localization in patients with breast carcinoma:
an immunohistologic study of 71 patients and review of the literature. Cancer.
2001;91(11):1973-82.
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Hakimelahi S, Parker HR, Gilchrist AJ,
Barry M, Li Z, Bleackley RC, Pasdar M. Plakoglobin regulates the expression of
the anti-apoptotic protein BCL-2. J Biol Chem. 2000;275(15):10905-11.
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Jouneau A, Yu YQ, Pasdar M, Larue L.
Plasticity of cadherin-catenin expression in the melanocyte lineage. Pigment
Cell Res. 2000;13(4):260-72.