Prof. Suling Liu

University of Michigan, USA

Email: suling.liu@gmail.com

Qualification

2003 Ph.D., The Ohio State University, Molecular and Cellular Biology

1997 B.Sc., University of Science and Technology of China, Biology

Publications (selected)

1. S. Liu*, S.H. Patel, C. Ginestier, I. Ibarra, R. Martin-Trevino, S. Bai, S. McDermott, L. Shang, J. Ke, S.J. Ou, A. Heath, K.J. Zhang, H. Korkaya, S.G. Clouthier, E. Charafe-Jauffret, D. Birnbaum, G.J. Hannon, and M.S. Wicha. MicroRNA93 Modulates Breast Cancer Stem Cells by Regulating their EMT/MET States, Proliferation and Differentiation (Revision in PlosBiology, *Corresponding Author).
2. S. Liu, S.G. Clouthier, M.S. Wicha. Role of microRNAs in the regulation of breast cancer stem cells. Journal of mammary gland biology and neoplasia February 14 (online), 2012.
3. J. Wu, S. Liu, G. Liu, A. Dombkowski, J. Abrams, R. Martin-Trevino, M.S. Wicha, S.P. Ethier, Z.Q. Yang. Identification and functional analysis of 9p24 amplified genes in human breast cancer.  Oncogene. 31(3):333-41, 2012. PMID: 21666724
4. S. Liu*, C. Ginestier, S.J. Ou, S.G. Clouthier, S.H. Shivani, F. Monville, H. Korkaya, A. Heath, J. Dutcher, C. Kleer, Y. Jung, G. Dontu, R. Taichman, M.S. Wicha*. Mesenchymal stem cells regulate breast cancer stem cells defining a cancer stem cell niche. Cancer Res 71(2); 614–24, 2011. (Cover featured, *Corresponding Author). PMID: 21224357
5. H. Korkaya, S. Liu, M.S. Wicha. Breast cancer stem cells, cytokine networks, and the tumor microenvironment. Journal of Clinical Investigation. 2011 Oct 3;121(10):3804-9. PMID: 21965337
6. I. Kryczek, S. Liu, M. Roh, L. Vatan, W. Szeliga, S. Wei, M. Banerjee, Y. Mao, J. Kotarski, M.S. Wicha, R. Liu, and W. Zou. Expression of aldehyde dehydrogenase and CD133 defines ovarian cancer stem cells. International Journal of Cancer. 2011. PMID: 21480217
7. H. Korkaya, S. Liu, M.S. Wicha*. Regulation of Cancer Stem Cells by Cytokine Networks: Attacking Cancers Inflammatory Roots.Clin Cancer Res. 17（19）：6125-6129，2011. PMID: 21685479.
8. S. Liu, M. S. Wicha. Targeting breast cancer stem cells. Journal of Clinical Oncology 28(25): 4006-4012, 2010. PMID: 20498387
9. Y. Li, T. Zhang, H. Korkaya, S. Liu, H.F. Lee, B. Newman, Y. Yu, S.G. Clouthier, S.J. Schwartz, M.S. Wicha, and D. Sun. Sulforaphane, a Dietary Component of Broccoli/Broccoli Sprouts, Inhibits Breast Cancer Stem Cells. Clinical Cancer Research 16(9):2580-90, 2010. PMID: 20388854
10. S.T. Shu, Y. Sugimoto, S. Liu, H.L. Chang, W. Ye, L.S. Wang, Y.W. Huang, P. Yan, Y.C. Lin. Function and regulatory mechanisms of the candidate tumor suppressor receptor protein tyrosine phosphatase gamma (PTPRG) in breast cancer cells. Anticancer Res. 30(6):1937-46, 2010. PMID: 20651337.
11. C. Ginestier, S. Liu, M.E. Diebel, H. Korkaya, M. Luo, J. Dutcher, M. Brown, E. Charafe-Jauffret, D. Birnbaum, J.L. Guan, G. Dontu, M.S. Wicha. CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts. JCI 120(2):485-97. PMID: 20051626
12. C. Ginestier, S. Liu, M.S. Wicha. Getting to the root of BRCA1-deficient breast cancer. Cell Stem Cell 5 (3): 229-230, 2009. PMID: 19733528
13. G Deniz, S. Liu, M.S. Wicha, A. Shukla, D Krag. Identification of Single Chain Antibodies to Breast Cancer Stem Cells Using Phage Display. Biotechnology progress 25(6):1780-7, 2009. PMID: 19899107
14. M. Luo, H. Fan, T. Nagy, H. Wei, C. Wang, S. Liu, M.S. Wicha, J.L. Guan. Mammary Epithelial-Specific Ablation of the Focal Adhesion Kinase Suppresses Mammary Tumorigenesis by Affecting Mammary Cancer Stem/Progenitor Cells. Cancer Research 62 (2): 466-474, 2009. PMID: 19147559
15. M. Kakarala, D.E. Brenner, H. Korkaya, C. Cheng, K. Tazi, C. Ginestier, S. Liu, G. Dontu, M.S. Wicha. Targeting breast stem cells with the cancer preventive compounds curcumin and piperine. Breast Cancer Res Treat. 2009. PMID: 19898931
16. H.L. Chang, Y. Sugimoto, S. Liu, L.S. Wang, Y.W. Huang, W. Ye, Y.C. Lin. Keratinocyte growth factor (KGF) regulates estrogen receptor-alpha (ER-alpha) expression and cell apoptosis via phosphatidylinositol 3-kinase (PI3K)/Akt pathway in human breast cancer cells. Anticancer Res. 29(8):3195-205, 2009.
17. S. Liu, C. Ginestier, E. Charafe-Jauffret, H. Foco, C.G. Kleer, S.D. Merajver, G. Dontu, M.S. Wicha. BRCA1 Regulates Human Mammary Stem/Progenitor Cell Fate. PNAS (USA) 105 (5): 1680-1685, 2008. PMID: 18230721
18. L.S. Wang, Y.W. Huang, S. Liu, P. Yan, Y.C. Lin. Conjugated linoleic acid induces apoptosis through estrogen receptor alpha in human breast tissue. BMC cancer 8: 208-221, 2008. PMID: 18652667
19. C. Ginestier, M.H. Hur, E. Charafe-Jauffret, F. Monville, J. Dutcher, M. Brown, J. Jacquemier, P. Viens, C.G. Kleer, S. Liu, A. Schott, D. Hayes, D. Birnbaum, M.S. Wicha, D. Dontu. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell 1: 555-567, 2007. PMID: 18371393
20. M.S. Updike, J.C. Sawdy, L.S. Wang, S. Liu, Y.W. Huang, W. Ye, W.B. Farrar, Y.C. Lin, M. Wick. Primary cultured human breast epithelial cells up-regulate protein disulfide isomerase in response to zeranol. Anticancer Res. 27(1A):407-10, 2007.
21. S. Liu, G. Dontu, I. Mantle, S. Patel, N. Ahn, K.W. Jackson, P. Suri, and M.S. Wicha. Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer Research 66: 6063-6071, 2006. PMID: 16778178
22. M.S. Wicha, S. Liu, and G. Dontu. Cancer Stem Cells: An Old Idea--A Paradigm Shift. Cancer Research 66(4): 1883-1890, 2006. PMID: 16488983