Prof. Michel Goldberg
Faculty of
Dental Medicine
University René Descartes, France
Email: michel.goldberg@parisdescartes.fr
Qualifications
2000 HUHSDM, Endodontics graduate program
1985 HUHSDM, Dental
Medicine
1982 HUHSDM, Basic Medical sciences
Publications (Selected)
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S. Opsahl, D. Septier, I. Aubin, J-L. Guenet, T. Sreenath, A. Kulkarni,
L. Vermelin, M. Goldberg. (2005) Is the lingual forming part of the incisor a
structural entity? Evidences from the fragilitas ossium (fro/fro)
mouse mutation and the TGFb1 over-expressing transgenic strain Archs
Oral Biol 50: 279-286.
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F. Priam, V.
Ronco, M. Locker, K. Bourd, M. Bonnefoix, T. Duchêne, J. Bitard, T. Wurtz, O.
Kellermann , M. Goldberg, A. Poliard (2005) New cellular models for
tracking the odontoblast phenotype Arch Oral Biol 50:
271-277.
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Bourd-Boittin
K, Fridman R, Fanchon S, Septier D, Goldberg M, Menashi S. (2005) Matrix
metalloproteinase inhibition impairs processing formation and mineralization of
dental tissues during mouse molar development. Experimental Cell
Research 304: 493-505.
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Lefeuvre M,
Amjaad W, Goldberg M, Stanislawski L. (2005) TEGDMA induces mitochondrial
damage and oxidative stress in human gingival fibroblasts. Biomaterials 26;
5130-5137.
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Aubin I, Adams
CP, Opsahl S, Septier D, Bishop CE, Auge N, Salvayre R, Negre-Salvayre A,
Goldberg M, Guenet JL, Poirier C. (2005) A deletion in the gene encoding
sphingomyelin phosphodiesterase 3 (Smpd 3) results in osteogenesis and
dentinogenesis imperfecta in the mouse. Nature Genetics 37:
803-805.
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Goldberg M., Septier D., Rapoport O., Iozzo R.V., Young M.F., Ameye
LG.(2005)Targeted disruption of two small leucine-rich proteoglycans, biglycan
and decorin, excerpts divergent effects on enamel and dentin formation. Calcif. Tissue Int 77: 297-310.
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GoldbergM, Septier D, Oldberg A, YoungMF, AmeyeLG (2006) Fibromodulin-deficient mice display impaired collagen fibrillogenesis in
predentin as well as altered dentin mineralization and enamel formation J
Histochem Cytochem 54: 525-537.
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Goldberg M,
Septier D, Limaye A, SreenathT, Kulkarni A.B. (2005) Dentin and enamel phenotype in Fabry mice. Oral Biosciences
& Medicine 2 : 265-271.
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Goldberg M, Lacerda-Pinheiro S, Chardin H, Jegat N, Septier D, Bonnefoix M,
Tompkin K, Veis A. (2004) Implantation of Two Low Molecular Weight Amelogenins
(A+4 and A-4) in the Pulp of Rat’s Maxillary Molars and in an Oral Mucosa
Ectopic Site. Proceedings of the 8th International Conference on the Chemistry
and Biology of Mineralized Tissues. W. Landis & J Sodek (co-chairs), pp
115-117.
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Moradian-OldakJ , GoldbergM. (2006) Amelogenin Supra-Molecular
Assembly In Vitro Compared to the Architecture of the Forming Enamel Matrix Cell
Tissue Organ 181 : 202-218.
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M. Goldberg, S. Lacerda–Pinheiro, N. Jegat, N. Six , D. Septier, F. Priam,
M. Bonnefoix, K. Tompkins, H. Chardin, P. Denbesten, A. Veis, A. Poliard.
(2006) The impact of bioactive molecules to stimulate tooth repair and
regeneration as part of restorative dentistry. Dental Clinics of North
America – (Special Issue on Tissue Engineering) 50 : 277-298.
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Bartlett JD, Ganss B, Goldberg M, Moradian-Oldak J, Paine ML, Snead ML, Wen
X, White SN, Zhou YL Protein-protein interactions of developing enamel matrix.
Chap. 3 In “Current topics in developmental biology”. Vol 74, Elsevier
2006, pp 57-115.
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Chaussain-MillerC, FiorettiF, GoldbergM, Menashi S. (2006)
The role of matrix metalloproteinases (MMPs) in human caries Crit Rev
Oral Biol Med 85: 22-32.
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Lacerda-PinheiroS, JegatN, SeptierD, PriamF, Bonnefoix M, Bitard J, KellermannO,
TompkinsK, VeisA, GoldbergM, Poliard A. (2006) Early in vivo and in
vitro effects of amelogenin gene splice products on pulp cells Eur
J Oral Sciences 114 (suppl 1) 232-238
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Haruyama N, Thyagarajan T, Skobe Z, Wright JT, Septier D, Sreenath TL,
Goldberg M, Kulkarni AB (2006) Overexpression of transforming growth factor-b1
in teeth results in detachment of ameloblasts and enamel defects. Eur J
Oral Sci 114 (suppl 1) 30-34.
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Lacerda-Pinheiro
S, Septier D, Tompkins K, Veis A, Goldberg M, Chardin H Amelogenin gene splice products A+4 and A-4 implanted in soft tissue
determine the reorientation of CD45-positive cells to an osteo-chondrogenic
lineage J Biomat Med Res 2006 ; 79 : 1015-22.
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Boskey AL, Goldberg M, Kulkarni A, Gomez S (2006) Infrared imaging
microscopy of bone : illustrations from a mouse model of Fabry disease. Biochim
Biophys Acta 1758 : 942-947.
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Priam F, Lacerda S, Bonnefoix M, Veis A, Goldberg M, Poliard A The Phenotype of Immortalized Odontoblast Progenitors. Adv Dent Res (in
press)
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BoukpessiT,
SeptierD, BaggaS, GarabedianM, Goldberg M, Chaussain-MillerC (2006) Dentin alteration of deciduous teeth in human hypophosphatemic ricketsCalcif
Tissue Int79 : 294-300.
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Chaussain-Miller C, SindingC, Septier
D, Wolikow M, Goldberg M, Garabedian M. (2007) Dentin Structure in Familial Hypophosphatemic Rickets: Benefits of Vitamin
D and Phosphate treatment Oral Diseases 13 : 482-489.
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Shapiro JL, Wen X, Okamoto CT, Wang HJ, Lyngstadaas SP, Goldberg M, Snead
ML, Paine ML. (2007) Cellular uptake of amelogenin, and its localization to
CD63, and Lamp1-positive vesicles Cellular Molecular Life
Sciences 64 : 244-256.
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SixN,
SeptierD, Chaussain-MillerC, Blacher R, DenBesten P, GoldbergM. Dentonin, a
MEPE fragment, initiates pulp healing response to injury J Dent Res 2007;
86: 780-785.
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JegatN, SeptierD, VeisA, PoliardA , GoldbergM. Short-term effects of
amelogenin gene splice products A+4 and A-4 implanted in the exposed rat molar
pulp. Head & Face Medicine 2007 ; 30, 40
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Goldberg M In vitro and in vivo studies
on the toxicity of dental resin components:a review. Clinical Oral
Investigation 2008 ; 12 : 1-8.
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Goldberg M, Lacerda-Pinheiro S, Priam F, Jegat N, Six N, Bonnefoix M,
Septier D, Chaussain-Miller C, Veis A, Denbesten P, Poliard A. Matricellular
molecules and odontoblast progenitors as tools for dentin repair and
regeneration. Clinical Oral Investigation 2008 ;12 :
109-112.
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GoldbergM, Ono M, Septier D, Bonnefoix M, Kilts TM, Bi Y, Embree M, Ameye
L, Young MF. Fibromodulin-deficient mice reveal dual functions for fibromodulin
in regulating dental tissue and alveolar bone formation. Cells Tissues
Organs (DOI/ 10.1159/000151370)
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Lacerda-PinheiroS, MarchadierA, DonãsP, SeptierD, Benhamou L , KellermannO,
GoldbergM, PoliardA. An in vivo model for short-term
evaluation of the implantation effects of biomolecules or stem cells in the
dental pulp Open Dent Journal 2008 ; 2 :67-72.
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GaucherC , BoukpessiT, SeptierD, Jehan F, RowePS, GarabédianM, GoldbergM,
Chaussain-MillerC. Dentin non-collagenous matrix proteins in familial
hypophosphatemic rickets.Cells Tissues Organs (DOI :
10.1159/000151382).
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Goldberg M, Farges J-C, Lacerda-Pinheiro S, Six N, Jegat N, Decup F,
Septier D, Carrouel F, Durand S, Chaussain-Miller C, DenBesten P, Veis A,
Poliard A. Inflammatory and immunological aspects of dental pulp repair Pharmacological
Research 2008 ; 58 : 137-147.
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Wen X, Zou YM, Luo W, Goldberg M, Moats R, Conti PS, Snead ML, Paine ML.
Biglycan overexpression on tooth enamel formation in transgenic mice. Anat
Rec 2008 ; 291: 1246-1253.
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Boukpessi T, Menashi S , Camoin L, TenCate JM, Goldberg M,
Chaussain-Miller C The effects of stromelysin-1 (MMP-3) on non-collagenous
extracellular matrix proteins of demineralized dentin and the adhesive
properties of restorative resins. Biomaterials (doi :
10.1016/j.biomaterials.2008.07.035).
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GoldbergM, SixN, Chaussain C, DenBestenP, VeisA, PoliardA.Dentin
extracellular matrix molecules implanted into exposed pulps generate reparative
dentin: a novel strategy in regenerative dentistry. J Dent Res 2009 ;
88 : 396-399.
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SuzukiS, SreenathT, HaruyamaN, HoneycuttC, Terse A, Cho A, Kohler T, Müller
R, Goldberg M, and. KulkarniAB. Dentin sialoprotein and dentin phosphoprotein
have distinct roles in dentin mineralization Matrix Biol doi: 10.1016/j.matbio.2009.03.006
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Goldberg M. Enamel, dentin and cementum : structure and composition-
potential consequences of resorative materials on the dental pulp and gingival
margin. In « Biocompatibility or cytotoxic effects of dental
composites » Goldberg M. editor. Oxford, COXMOOR PUBLISHING Company 2009,
pp 53- 71.
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Goldberg M. Short-term release of free monomers and long-term degradation
of resin-based materials. In « Biocompatibility or cytotoxic effects of
dental composites » Goldberg M. editor. Oxford, COXMOOR PUBLISHING Company
2009, pp 75-79.
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Goldberg M . Repair or regeneration, a short review. In
« Biocompatibility or cytotoxic effects of dental composites »
Goldberg M. editor. Oxford, COXMOOR PUBLISHING Company 2009, pp 181-184.
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Boukpessi T, Septier D, Goldberg M. Animal studies. In « Biocompatibility
or cytotoxic effects of dental composites » Goldberg M. editor. Oxford,
COXMOOR PUBLISHING Company 2009, pp 200-203.
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Goldberg M, Grootveld M, Lynch E. Undesirable and adverse effects of Tooth
Whitening Products - a review. Clinical Oral Investigation 2010 ;14 :
1-10.
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Li W, Sire J-Y, Takano Y, MacDougall M, Goldberg M, DenBesten P. Amelogenin
exon 8 and 9. In « Amelogenins : multifaceted proteins for
dental and bone formation and repair. M. Goldberg ed Bentham 2010, pp 163 -
173
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Harichane Y, Dimitrova-Nakov S, Poliard A, Veis A, DenBesten P, Kellermann,
Goldberg M. In vivo effects of amelogenins on reparative dentin formation.
In « Amelogenins : multifaceted proteins for dental and bone
formation and repair. M. Goldberg ed. Bentham 2010, pp 174- 190.
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GoldbergM, KulkarniAB, YoungM, BoskeyA.Dentin: Structure, Composition and
ineralization.- The role of dentin ECM in dentin formation and mineralization. Front
BioSci (Elite Ed). 2011 Jan 1;3:711-735.
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Goldberg M, Schmalz G. Editorial : Toward a strategic
plan for pulp healing: from repair to regeneration. Clinical Oral
Investigation 2011; 15:1-2.
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Goldberg
M.Pulp Healing and Regeneration: More Questions Than Answers. Advances
in Dental Research/J Dent Res 2011, accepted for publication.
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GoldbergM, MarchadierA, VidalC, HarrichaneY, Kamoun-GoldratA, KellermannO,
KiltsT, YoungM. Differential effects of fibromodulin deficiency on mouse
mandibular bones and teeth - a microCT time course study. Cells,
Tissues, Organs, accepted for publication.
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Harichane Y, Hirata A, Dimitrova-Nakov S, Granja I, Goldberg M,
Kellermann O, Poliard A. Pulpal progenitors and dentin repair. Advances
in Dental Research/Journal Dental Research, accepted for publication.