Dr. Jack Wing Tak Wong

Stanford University School of Medicine, USA

Email: jack_wingtak@yahoo.com

Qualifications

2010 Postdoctoral Fellow, Stanford School of Medicine, USA

2010 Postdoctoral Fellow, School of Biomedical Sciences, Chinese University of Hong Kong, Hong Kong, China

2009 Ph.D., Physiology, Department of Physiology, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong, China

2005 B.Sc., Chinese Medicine and Bachelor of Biomedical Sciences, Hong Kong Baptist University, Hong Kong, China

Publications(Selected)

1. Sayed N, *Wong WT, Ospino F, Meng S, Lee J, Jha A, Dexheimer P, Aronow B, Cooke JP (2015). Transdifferentiation of Human Fibroblasts to Endothelial Cells: Role of Innate Immunity. Circulation. 131(3):300-9. *Co-first author.
2. Liu J, Wang L, Tian X, Liu L, Wong WT, Zhang Y, Han Q, Ho HM, Wang N, Wong SL, Chen Z, Yu J, Ng CF, Yao X, Huang Y (2015). Unconjugated bilirubin mediates heme oxygenase-1-induced vascular benefits in diabetic mice. Diabetes. In Press.
3. Cheang WS, Tian XY, Wong WT, Huang Y (2015). Peroxisome proliferator-activated receptors in cardiovascular diseases: experimental benefits and clinical challenges. British Journal Pharmacology. In Press.
4. Cooke JP, Sayed N, Lee J, Wong WT (2014). Innate immunity and epigenetic plasticity in cellular reprogramming. Current Opinion in Genetics & Development. 28:89-91.
5. Cheang WS, Tian XY, Wong WT, Lau CW, Lee ST; Chen ZY, Yao X, Wang N & Huang Y (2014) Metformin protects endothelial function in diet-Induced obese mice by inhibition of endoplasmic reticulum stress through AMPK-PPARδ pathway. Arteriosclerosis, Thrombosis and Vascular Biology 34(4):830-6.
6. Zhang Y, Liu J, Tian XY, Wong WT, Chen Y, Wang L, Luo J, Cheang WS, Lau CW, Kwan KM, Wang N, Yao X, Huang Y (2014). Inhibition of Bone Morphogenic Protein 4 Restores Endothelial Function in db/db Diabetic Mice. Arterioscler Thromb Vasc Biol. 34(1):152-159.
7. Wong WT, Tian XY, Huang Y (2013). Endothelial Dysfunction in Diabetes and Hypertension: Cross Talk in RAS, BMP4 and ROS-dependent COX-2-derived Prostanoids. J Cardiovascular Pharmacology 61(3):204-14
8. Cheang WS, Lam MY, Wong WT, Tian XY, Zhu Z, Yao X, Huang Y (2013) Menthol relaxes rat aortae, mesenteric and coronary arteries by blocking L-type calcium channels. European Journal of Pharmacology (1-3):79-84.
9. Yung LM, Tian XY, Wong WT, Leung FP, Yung LH, Chen ZY, Lau CW, Yao X, Huang Y (2013). Chronic consumption of cranberry juice restores cholesterol profiles and endothelial function during estrogen deficiency. European Journal of Nutrition 52(3):1145-55.
10. Tian XY, *Wong WT, Wang NP, Lu Y, Cheang WS, Liu J, Liu L, Liu Y, Lee SS, Chen ZY, Cooke JP, Yao X, Huang Y (2012). PPARδ activation protects endothelial function in diabetic mice. Diabetes 61(12):3285-93(*Co-first author)
11. Liu L, Liu J, Wong WT, Tian XY, Lau CW, Wang YX, Xu G, Pu Y, Zhu ZM, Xu A, Lam KS, Chen ZY, Ng CF, Yao X, Huang Y (2012). Dipeptidyl Peptidase-4 Inhibitor Sitagliptin Protects Endothelial Function in Hypertension through GLP-1 Dependent Mechanism. Hypertension 60(3):833-41
12. Wong WT, Huang NF, Botham CM, Sayed N, Cooke JP (2012). Endothelial cells derived from nuclear reprogramming. Circulation Research 2012;111(10):1363-75.
13. Tian XY, *Wong WT, Xu A, Lu Y, Zhang Y, Wang L, Cheang WS, Wang Y, Yao X, Huang Y (2012).
14. Uncoupling Protein-2 Protects Endothelial Function in Diet-Induced Obese Mice. Circulation Research 110(9):1211-6. (*Co-first author)
15. Tian XY, *Wong WT, Wang YX, Leung FP, Ng CF, Wang YX, Lee HK, Yao X, Au CL, Lau CW, Vanhoutte PM, Cooke JP, Huang Y (2012) ROS-stimulated production of cyclooxygenase-2-derived prostaglandin F2 cause endothelial dysfunction and impaired renal blood flow in renovascular hypertensive rats. Antioxidant & Redox Signaling 16(4):363-73. (*Co-corresponding author)
16. Tian XY, Yung LH, Wong WT, Leung FP, Chen YC, Kong SK, Ng SM, Lai PB, Yung LM, Yao X & Huang Y (2012) Bone morphogenic protein-4 induces endothelial cell apoptosis through oxidative stress-dependent
17. p38MAPK and JNK pathway. Journal of Molecular and Cellular Cardiology 52(1):237-44
18. Tian XY, Wong WT, Sayed N, Lau CW, Luo J, Tsang SY, Leung FP, Bian ZX, Yao X, Chen ZY, Huang Y (2012) NaHS relaxes rat and mouse cerebral artery through inhibition of L-type Ca2+ channels. Pharmacological Research 65(20:239-246 (Co-corresponding author)
19. Leung JW, Wong WT, Koon HW, Mo FM, Tam S, Huang Y, Vanhoutte PM, Chung SS, Chung SK (2011).
20. Transgenic Mice Over-Expressing ET-1 in the Endothelial Cells Develop Systemic Hypertension with Altered Vascular Reactivity. PLoS One 6(11):e26994.
21. Cheang WS, Wong WT, Tian XY, Yang Q, Lee HK, He GW, Yao X, Huang Y (2011) Endothelial nitric oxide synthase enhancer reduces oxidative stress and restores endothelial function in db/db mice. Cardiovascular Research 92(2):267-75.
22. Wong WT, Tian XY, Xu A, Yu J, Lau CW, Hoo RL, Wang Y, Lee VWY, Lam KS, Vanhoutte PM, Huang Y (2011) Adiponectin is required for PPARγ-mediated improvement of endothelial function in diabetic mice. Cell Metabolism 2011;14(1):104-15.
23. *Wong WT, Tian XY, Chen YC, Leung FP, Liu LM, Lee HK, Ng CF, Xu A, Yao X, Vanhoutte PM, Tipoe GL, Huang Y (2010). Bone morphogenic protein-4 impairs endothelial function through oxidative stress-dependent cyclooxygenase-2 upregulation: implications on hypertension. Circulation Research 107(8):984-91 (*Cocorresponding author)
24. Wong WT, Tian XY, Xu A, Ng CF, Lee HK, Chen ZY, Au, CL, Yao X, Huang Y (2010). Angiotensin II type 1 receptor-dependent oxidative stress mediates endothelial dysfunction in diabetic mice. Antioxidants & Redox Signaling 15;13(6):757-68.
25. Tian XY, Wong WT, Xu A, Chen ZY, Liu L, Cheang WS, Lee VWY, Lau CW, Yao X & Huang Y (2011) Rosuvastatin Improves Endothelial Function of db/db Mice: Role of Angiotensin II Type 1 Receptors and Oxidative Stress. British Journal of Pharmacology 164(2b):598-606.(Co-corresponding author).