Prof. Cassian Sitaru
University of Freiburg, Germany
Email: cassian.sitaru@uniklinik-freiburg.de
Qualifications
1998 Ph.D., Babes-Bolyai University,
Cluj-Napoca, Romania
1996 M.D., Iuliu Hatieganu University,
Cluj-Napoca, Romania
Publications (Selected)
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Kromminga A, Sitaru C, Meyer J, Arndt R,
Schmidt E, Christophers E, Br¨ocker EB, Zillikens D. Cicatricial pemphigoid
differs from bullous pemphigoid and pemphigoid gestationis regarding the fine
specificity of autoantibodies to the BP180 NC16A domain. J Dermatol Sci
28:68-75, 20022 (IF 1.270)3
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Sitaru C, Schmidt E, Petermann S, Munteanu LS,
Br¨ocker EB, Zillikens D. Autoantibodies to bullous pemphigoid antigen 180
induce dermal-epidermal separation in cryosections of human skin. J Invest Dermatol
118:664-671, 2002.(IF 4.593)
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Sitaru C, Kromminga A, Hashimoto T, Br¨ocker EB,
Zillikens D. Autoantibodies to type VII collagen from patients with
epidermolysis bullosa acquisita mediate Fcγ-dependent neutrophil recruitment
and induce dermal-epidermal separation in cryosections of human skin. Am J
Pathol 161:301-11, 2002. (IF 6.971)
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Schmidt E, Kromminga A, Mimietz S, Leinfelder U, Sitaru
C, Br¨ocker EB, Zillikens D, Zimmermamnn U. A highly sensitive and specific
assay for the detection of circulating autoantibodies against full-lenght
bullos pemphigoid antigen 180. J Autoimmun 18:299-309, 2002. (IF 2.176)
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Leyendeckers H, Tasanen K, Bruckner-Tuderman L,
Zillikens D, Sitaru C, Schmitz J, Hunzelmann N. Memory B cells specific
for the NC16A Domain of the 180 kDa bullous pemphigoid autoantigen can be
detected in peripheral blood of bullous pemphigoid patients and induced in
vitro to synthesize autoantibodies. J Invest Dermatol 120:1-7, 2003. (IF
4.593)
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Schmidt E, Klinker E, Opitz A, Sitaru C,
Herzog S, Goebeler M, Br¨ocker EB, Zillikens D. Protein A immunoadsorption: A
novel and effective adjuvant treatment of pemphigus. Br J Dermatol 148:
1222-1229, 2003. (IF 2.659)
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Hirako Y, Nishizawa Y, Sitaru C, Opitz O,
Marcus K, Meyer HE, Butt E, Owaribe K,
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Zillikens D. The 97 kDa (LABD97) and 120 kDa
(LAD-1) fragments of type XVII collagen/BP180 have different N-Termini. J
Invest Dermatol 121:1554-1556, 2003. (IF 4.593)
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Shimanovich I, Hirako Y, Sitaru C, Butt E,
Hashimoto T, Br¨ocker EB, Zillikens D. The autoantigen of anti-p200 pemphigoid
is an acidic noncollagenous N-linked glycoprotein of the cutaneous basement
membrane. J Invest Dermatol 121:1402-1408, 2003. (IF 4.593)
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Sitaru C, Powell J, Messer G, Br¨ocker E-B,
Wojnarowska F, and Zillikens D. Immunoblotting and enzyme-linked immunosorbent
assay for the diagnosis of pemphigoid gestationis. Obstet Gynecol, 103:757-763,
2004. (IF 2.202)
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Kromminga A, Sitaru C, Hagel C, Herzog S,
Arndt R, Br¨ocker E-B, and Zillikens D. Development of an ELISA for the
detection of autoantibodies to recombinant BP230. Clin Immunol, 111:146-52,
2004. (IF 2.564)
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Shimanovich I, Mihai S, Oostingh G J, Ilenchuk
T, Br¨ocker E-B, Opdenakker G, Zillikens D, Sitaru C. Granulocyte-derived
elastase and gelatinase B are required for dermal-epidermal separation induced
by autoantibodies from patients with epidermolysis bullosa acquisita and
bullous pemphigoid. J Pathol 204: 519-527, 2004. (IF 4.933)
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Schmausser B, Josenhans C, Endrich S, Suerbaum
S, Sitaru C, Androulis M, Br¨andlein S, Rieckmann P, M¨ uller-Hermelink
HK, Eck M. CXCR1 and CXCR2 expression on human neutrophils is downregulated by
Helicobacter pylori: a new pathomechanism in H. pylori infection? Infect Immun
72:6773-6779, 2004. (IF 3.875)
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Lazarova Z, Sitaru C, Zillikens D, Yancey
KB. Comparative analysis of methods for detection of anti-laminin 5
autoantibodies in patients with anti-epiligrin cicatricial pemphigoid. J Am
Acad Dermatol 51:886-92, 2004. (IF 2.659)
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Oostingh GJ, Sitaru C, Kromminga A, L¨uhrs
H, Zillikens D. Subclass distribution of collagen type VII specific
autoantibodies in patients with inflammatory bowel diseases. J Dermatol Sci,
37:182-4, 2005. (IF 1.270)
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Sitaru C, Mihai S, Otto C, Chiriac MT, Hau遝r I, Dotterweich B, Saito H, Rose C, Ishiko A, Zillikens D. Induction of
dermal-epidermal separation in mice by passive transfer of antibodies to type
VII collagen. J Clin Invest, 115:870-878, 2005. (IF 14.300)
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Herrero-Gonzalez JE, Sitaru C, MD; Klinker
E, Br¨ocker EB, Zillikens D. Successful adjuvant treatment of severe bullous
pemphigoid by tryptophan immunoadsorption. Clin Exp Dermatol, 30:519-22, 2005.
(IF 1.220)
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Espa˜na A, del O’lmo J, Marquina M, Sitaru
C. Penfigoide de mucosas: anticuerpos IgG e IgA contra el antigeno BP180. Actas
Dermo-Sifiliograficas, 96:365-371, 2005.
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Herrero-Gonzalez JE, Brauns O, Egner R,
R¨onspeck W, Mascar′o JM, Jonkman MF, Zillikens D, Sitaru C.
Immunoadsorption against two distinct epitopes on human type XVII collagen
abolishes dermal-epidermal separation induced invitro by
autoantibodies from pemphigoid gestationis patients.Eur J Immunol, 36:1039-48,
2006. (IF 5.01).
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Olaru F, Mihai S, Petrescu I, Zillikens D, Sitaru
C. Generation and characterization of monoclonal antibodies against the
intracellular domain of hemidesmosomal type XVII collagen. Hybridoma,
25:158-163, 2006. (IF 0.326)
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Sitaru C, Chiriac MT, Mihai S, B¨uning J, Gebert
A, Ishiko A, Zillikens D. Induction of complement-fixing autoantibodies against
type VII collagen results in subepidermal blistering in mice. J Immunol,
177:3461-8, 2006. (IF 6.387)
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Liu Z, Sui W, Zhao M, Li Z, Li N, Thresher R,
Giudice GJ, Fairley JA, Sitaru C, Zillikens D, Ning G, Marinkovich MP,
Diaz LA. Subepidermal blistering induced by human autoantibodies to BP180
requires innate immune players in a humanized bullous pemphigoid mouse model. J
Autoimmunity, 31:331-8, 2008. (IF 7.8)
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Sitaru AG, Sesarman A, Mihai S, Chiriac MT,
Zillikens D, Solbach W, Hultman P, SitaruC. T cells are required for the
production of blister-inducing autoantibodies in experimental epidermolysis
bullosa acquisita. J Immunol, 184:1596-603, 2010. (IF 6)
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Recke A, Sitaru C, Vidarsson G, Evensen M,
Chiriac MT, Ludwig RJ, Zillikens D. Pathogenicity of IgG subclass
autoantibodies to type VII collagen: induction of dermalepidermal separation..
J Autoimmunity, 34:435-44, 2010. (7.8)
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Csorba K, Sesarman A, Oswald E, Feldrihan V,
Fritsch A, Sitaru C. Cross-reactivity of autoantibodies from patients with
epidermolysis bullosa acquisita with murine collagen VII. Cell Mol Life Sci,
67:1343-51, 2010. (IF 6.01)
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Baican A, Baican C, Chiriac G, Chiriac MT,
Macovei V, Zillikens D, Ciuce D, Sitaru C. Pemphigus vulgaris is the most
common autoimmune bullous disease in Northwestern Romania. Int J Dermatol,
49:768-774. (IF 1.17)
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Nishie W, Lamer S, Schlosser A, Licarete E,
Franzke CW, Hofmann SC, Jackow J, Sitaru C, Bruckner-Tuderman L.
Ectodomain shedding generates neoepitopes on collagen XVII: role in autoimmune
blistering diseases. J Immunol, 15;185:4938-47, 2010. (IF 6)
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Kulkarni S, Sitaru C, Jakus Z, Anderson KE,
Davidson D, Hirose M, Oxley D, Chessa TAM, Ramadani F, Guillou H,
Segonds-Pichon A, Fritsch A, Jarvis GE, Okkenhaug K, Ludwig RJ, Zillikens D,
Mocsai A, van Haesebroeck B, Stephens LR, Hawkins PT. Essential role for PI3Kβ in
neutrophil activation by immune complexes. Sci Signal, 4(168):ra23, 2011.
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Csorba K, Schmidt S, Florea F, Ishii N,
Hashimoto T, Hertl M, K′ arp′ ati S, Bruckner- Tuderman L, Nishie W, Sitaru
C. Development of an ELISA for sensitive and specific detection of IgA
autoantibodies against BP180 in pemphigoid diseases. Orphanet J Rare Dis,
28;6:31, 2011. (IF 5.8)
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van der Steen L, Bakema JE, Tuk CW, Sesarman A,
Kirtschig G, Sitaru C, van Egmond M. IgA-FcαRI interactions induce severe
tissue damage in chronic inflammatory diseases. Submitted
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Sesarman A, Oswald E, Chiriac MT, Csorba K, Vuta
V, Feldrihan V, Bruckner-Tuderman L, Sitaru C. Interaction of human IgG
autoantibodies with murine innate immunity factors: implications for disease
models using the passive transfer of IgG. Immunol Lett, in press (DOI:
10.1016/j.imlet.2012.01.006).
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Oswald E, Sesarman A, Franzke CW, W¨olfle U,
Bruckner-Tuderman L, Jakob T, Martin SF, Sitaru C. The flavonoid luteolin
inhibits Fcγ-dependent respiratory burst in granulocytes, but not skin
blistering in a new model of pemphigoid in adult mice PLoS ONE, in press
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Chiriac MT, Licarete E, Sas AG, Rados AM, Lupan
I, Chiriac AM, Speth H, Pop- Vancia V, Domsa I, Sesarman A, Popescu O, Sitaru
C. Sheep antibodies to collagen XVII/BP180 are pathogenic in a novel model of
bullous pemphigoid in adult wild-type mice. Submitted
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Csorba K, Florea F, Licarete E, Vuta V,
Bruckner-Tuderman L, Sitaru C. Mapping of pathogenic epitopes in experimental
epidermolysis bullosa acquisita. Submitted
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Licarete E, Ganz G, Recknagel MJ, Di Zenzo G,
Hashimoto T, Hertl M, Zambruno G, Hundorfean G, Mudter J, Neurath MF,
Bruckner-Tuderman L, Sitaru C. Prevalence of collagen VII-specific
autoantibodies in patients with autoimmune and inflammatory diseases. Submitted
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Sitaru C, Csorba K, Licarete E, Nemeth N,
Bruckner-Tuderman L, Mocsai A. Spleen tyrosine kinase (Syk) promotes
granulocyte-mediated skin blistering induced by autoantibodies. Submitted
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Vuta V, Nystr¨om A, Csorba K, Koch M, Keene DR,
Bruckner-Tuderman L, Sitaru C. Non-inflammatory pathogenic effects of collagen
VII-specific autoantibodies. Submitted.