Dr. Valery Leytin

Ryerson University, Canada

Adjunct Professor

Email: leytinv@smh.toronto.on.ca

Qualifications

1988 D.Sc., Cardiology Research Center, Cardiology & Biochemistry

Publications (Selected)

1. Gyulkhandanyan AV, Mutlu A, Allen DJ, Freedman J, Leytin V. BH3-mimetic ABT-737 induces strong mitochondrial membrane depolarization in platelets but only weakly stimulates apoptotic morphological changes, platelet shrinkage and microparticle formation. Thromb Res 133:73-9, 2014.
2. Mutlu A, Gyulkhandanyan AV, Freedman J, Leytin V. Concurrent and separate inside-out transition of platelet apoptosis and activation markers to the platelet surface. Br J Haematol 163:377-84, 2013.
3. Gyulkhandanyan AV, Mutlu A, Freedman J, Leytin V. Selective triggering of platelet apoptosis,platelet activation or both. Br J Haematol 161:245-54, 2013.
4. Mutlu A, Gyulkhandanyan AV, Freedman J, Leytin V. Activation of caspases-9, -3 and -8 in human platelets triggered by BH3-only mimeticABT-737 and calcium ionophore A23187: caspase-8 is    activated via bypass of the death receptors. Br J Haematol 159:565-71, 2012.
5. Gyulkhandanyan AV, Mutlu A, Freedman J, Leytin V. Markers of platelet apoptosis: methodology and applications. J Thromb Thrombolysis 33:397-411, 2012.
6. Leytin V. Apoptosis in the anucleate platelet. Blood Rev 26:51-63, 2012.
7. Leytin V, Mutlu A, Mykhaylov S, Allen DJ, Gyulkhandanyan AV, Freedman J. The GPIIbIIIa antagonist drugs eptifibatide and tirofiban do not induce activation of apoptosis executioner caspase-3 in resting human platelets but inhibit caspase-3 activation in platelets stimulated with thrombin or calcium ionophore A23187. Haematologica 94:1783-4, 2009.
8. Leytin V, Allen DJ, Mutlu A, Mykhaylov S, Lyubimov E, Freedman J. Stored platelet concentrates produced by the platelet-rich plasma method are more resistant to apoptosis but more sensitive to activation than are platelets prepared by the buffy-coat and apheresis methods. Transfusion, 49:1493-4, 2009.
9. Leytin V, Allen DJ, Mutlu A, Gyulkhandanyan AV, Mykhaylov S, Freedman J. Mitochondrial control of platelet apoptosis: Effect of cyclosporin A, an inhibitor of the mitochondrial permeability  transition pore. Lab Invest, 89:374-84, 2009.
10. Leytin V, Allen DJ, Mutlu A, Mykhaylov S, Lyubimov E, Freedman J. Platelet activation and apoptosis are different phenomena: evidence from the sequential dynamics and the magnitude of responses during platelet storage. Br J Haematol 142:494-7, 2008.