Prof. Markus
J. Seibel
The University
of Sydney, Australia
Email:
mjs@anzac.edu.au
Qualifications
1997 Ph.D., University of Heidelberg, Germany
1984 M.D., University of Mainz, Germany
Publications (selected)
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Ooi LL, Zhou
H, Kalak R, Zheng Y, Conigrave AD, Seibel MJ, Dunstan CR. Vitamin D deficiency
promotes human breast cancer growth in a murine model of bone metastasis. Cancer
Res 70: 1835-44, 2010.
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Weber AJ, Li
G, Kalak R, Street J, Buttgereit F, Dunstan CR, Seibel MJ, Zhou H.
Osteoblast-targeted disruption of glucocorticoid signaling does not delay
intramembranous bone healing. Steroids. 2010 [Epub ahead of print].
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Birzniece V,
Meinhardt U, Gibney J, Johannsson G, Baxter RC, Seibel MJ, Ho KY Modulatory
Effect of Raloxifene and Estrogen on the Metabolic Action of Growth Hormone in
Hypopituitary Women. J Clin Endocrinol Metab 2010 (in press)
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Wong T, Girgis
C, Ngu MC, Chen RY, Emmett L, Archer KA, Seibel MJ. Hypophosphatemic
Osteomalacia after Low-Dose Adefovir Dipivoxil Therapy for Hepatitis B. J Clin
Endocrinol Metab 95(2):479–480, 2010.
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Zhou H, Mak W,
Kalak R, Street J, Fong-Yee C, Zheng Y, Dunstan C, Seibel MJ. Glucocorticoid
Dependent Wnt Signaling by Mature Osteoblasts Is a Key Regulator of Cranial
Skeletal Development in Mice. Development 136; 427-436, 2009.
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Blair JM;
Modzelewski JR; Perryman LA; Russell P, Seibel MJ; Dunstan CR. Prolonged
anti-resorptive treatment of lytic prostate cancer xenografts in mouse bone
results in tumour necrosis. J Cancer Molec 2009 (in press)
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Buttgereit F,
Zhou H, Kalak R, Gaber T, Spies CM, Huscher D, Straub RH, Modzelewski J,
Dunstan CR, Seibel MJ. Transgenic disruption of glucocorticoid signaling in
mature osteoblasts and osteocytes attenuates K/BxN mouse serum-induced
arthritis in vivo. Arthritis Rheum 60: 1998-2007, 2009.
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Kalak R, Zhou
H, Dunstan C, Day R, Modzelewski J, Li G, Seibel MJ. Endogenous glucocorticoid
signaling in osteoblasts is necessary to maintain normal bone structure in
mice. Bone 45: 61-7, 2009
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Chen JS,
Sambrook PN, Simpson JM, Cameron ID, Cumming RG, Seibel MJ, Lord SR, March LM
Risk factors for hip fracture among institutionalised older people. Age & Ageing
38: 429-34, 2009
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Cumming RG,
Handelsman D, Seibel MJ, Creasey H, Sambrook P, Waite L, Naganathan V, Le
Couteur D, Litchfield M. Cohort Profile: the Concord Health and Ageing in Men
Project. Intl J Epidemiol. 38: 374-8, 2009.
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Cameron ID,
Chen JS, March LM, Simpson JM, Cumming RG, Seibel MJ, Sambrook PN. Hip Fracture
Causes Excess Mortality Due to Cardiovascular and Infectious Disease in
Institutionalized Older People: A Prospective Five-Year Study. J Bone Miner
Res. 2009 Oct 19. [Epub ahead of print]
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Mak W, Shao X,
Dunstan CR, Seibel MJ, Zhou H Biphasic Glucocorticoid-Dependent Regulation of
Wnt Expression and Its Inhibitors in Mature Osteoblastic Cells. Calcif Tissue
Int 85:538-45, 2009.
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Lee P,
Greenfield JR, Seibel MJ, Eisman JA, Center JR. Adequacy of vitamin D
replacement in severe deficiency is dependent on body mass index. Am J Med.
122: 1056-60, 2009.
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Chen JS,
Sambrook PN, March L, Cameron ID, Cumming RG, Simpson JM, Seibel MJ. Hypovita-minosis
D and parathyroid hormone response in the elderly: effects on bone turnover and
mortality. Clin Endocrinol (Oxf) 68: 290-8, 2008.
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Neudert M,
Fischer C, Krempien B, Seibel MJ, Bauss F A histological score
for the evaluation of osteolytic tumour burden in experimental breast cancer
metastases. Onkologie 31: 521-527, 2008
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Nelson AE,
Meinhardt U, Hansen, Walker I, Stone G, Howe CJ, Leung C, Seibel MJ, Baxter RC,
Handelsman DJ, Kazlauskas R, Ho KK. Pharmacodynamics of GH abuse biomarkers and
the influence of gender and testosterone: a randomized double-blind
placebo-controlled study in young recreational athletes. J Clin Endocrin
Metabolism 93: 2213-22, 2008.
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Sànchez L,
Wilson N, Kok C, Sambrook PN, Cumming R, Cameron ID, Chen JS, Simpson J, Mason
RS, Seibel MJ, March LM. Trends in calcium and vitamin D usage among older
people in nursing care facilities in Australia: still falling short of the
guidelines. Int J Rheum Dis 2008; 11: 430–434
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Zheng Y, Zhou
H, Fong C, Modzelewski JR, Seibel MJ, Dunstan CR. Bone resorption increases
tumour growth in osteosclerotic breast cancer metastasis. Clin Exp Metastasis
25: 559-67, 2008.
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Nguyen TV,
Nelson AE, Howe CJ, Seibel MJ, Baxter RC, Handelsman DJ, Kazlauskas R, Ho KK
Within-subject variability and analytic imprecision of IGF axis and collagen
markers in healthy individuals. Clin Chemistry 54: 1268-76, 2008
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Zhou H, Mak W,
Zheng Y, Dunstan C, Seibel MJ Osteoblasts directly control lineage
commitment of mesenchymal progenitor cells through WNT signaling. J Biol Chem
283: 1936-45, 2008
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Lee P, Seibel
MJ More on atypical fractures of the femoral diaphysis. NEJM 359:3, 316-318,
2008
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Buttgereit F,
Zhou H, Seibel MJ. Arthritis and endogenous glucocorticoids: the emerging role
of the 11 beta HSD-enzymes. Editorial. Ann Rheum Dis 67 (9): 1201-1203, 2008 .
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Meier C,
Nguyen TV, Handelsman DJ, Schindler C, Center JR, Eisman JA, Seibel
MJ Serum Testosterone is Associated with Incident Fracture
Risk in Older Men: The Dubbo Osteoporosis Epidemiology Study. Arch Int Medicine
168: 47-54, 2008.
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Chen JS,
Simpson JM, March LM, Cameron ID, Cumming RG, Lord SR, Seibel MJ, Sambrook PN.
Risk Factors for Fracture Following a Fall Among Older People in Residential
Care Facilities in Australia. J Am Geriatr Soc. 2008 Sep 22. [Epub ahead of
print]
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Blyth FM,
Rochat S, Cumming R, Handelsman D, LeCouteur D, Naganathan V, Sambrook PN,
Seibel MJ. Pain, Frailty and Comorbidity in Older Men: the CHAMP study. Pain
2008 Oct 1. [Epub a.o.p.]
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Cumming RG,
Handelsman D, Seibel MJ, Creasey H, Sambrook P, Waite L, Naganathan V, Couteur
DL, Litchfield M. Cohort profile: The Concord Health and Ageing in Men Project
(CHAMP). Int J Epidemiol. 2008 May 14. [Epub ahead of print].
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Nguyen TV,
Nelson AE, Howe CJ, Seibel MJ, Baxter RC, Handelsman DJ, Kazlauskas R, Ho KK
Within-subject variability and analytic imprecision of IGF axis and collagen
markers in healthy individuals. Clin Chemistry Jun 20, 2008 [Epub ahead of
print] PMID: 18567697
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Chen JS,
Simpson JM, March LM, Cameron ID, Cumming RG, Lord RS, Seibel MJ, Sambrook
PN. Fracture risk assessment in frail older people using clinical
risk factors. Age and Ageing 2008