Dr. Cheng-Xin Gong
New
York State Institute for Basic Research in Developmental Disabilities, USA
Email: chengxin.gong@csi.cuny.edu
Qualifications
1988
M.D., Tongji Medical University
1983
M.S., Xianning Medical College
Publications (selected)
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Liu,
F, Iqbal, K, Grundke-Iqbal, I, Hart, GW, and Gong, CX. O-GlcNAcylation
regulates phosphorylation of tau: A mechanism involved in Alzheimer's disease.
Proc Natl Acad Sci USA. 2004; 101: 10804-10809.
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Liu,
F, Iqbal, K, Grundke-Iqbal, I, Rossie, S, Gong, CX. Dephosphorylation of
tau by protein phosphatase 5: Impairment in Alzheimer disease. J. Biol. Chem.
2005; 280: 1790-1796.
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Liu,
F, Grundke-Iqbal, I, Iqbal, K, Oda, Y, Tomizawa, K, Gong, CX. Truncation
and activation of calcineurin A by calpain l in Alzheimer disease brain. J.
Biol. Chem. 2005; 280: 37755-37762.
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Deng,
Y, Li, B, Liu, F, Iqbal, K, Grundke-Iqbal, I, Brandt, R, Gong, CX.
Regulation between O-GlcNAcylation and phosphorylation of neurofilament-M and
their dysregulation in Alzheimer disease. FASEB J. 2008; 22 (1): 138-45.
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Liu
F, Liang Z, Wegiel J, Hwang YW, Iqbal K, Grundke-Iqbal I, Ramakrishna N, Gong
CX. Overexpression of Dyrk1A contributes to neurofibrillary degeneration in
Down syndrome. FASEB J. 2008; 22 (9): 3224-33.
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Liu
F, Shi J, Tanimukai H, Gu J, Gu J, Grundke-Iqbal I, Iqbal K, Gong CX. Reduced
O-GlcNAcylation links lower brain glucose metabolism and tau pathology in
Alzheimer disease. Brain 2009; 132: 1820-32.
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Deng
Y, Li B, Liu Y, Iqbal K, Grundke-Iqbal I, Gong CX. Dysregulation of insulin
signaling, glucose transporters, O-GlcNAcylation, and phosphorylation of tau
and neurofilaments in the brain: Implication for Alzheimer's disease. Am J
Pathol. 2009; 175 (5): 2089-2098.
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Gong,
C.-X., Grundke-Iqbal, I., Iqbal, K. Targeting tau protein in Alzheimer disease.
Drug Aging. 2010; 27 (5): 351-65.
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Liu
Y, Liu F, Grundke-Iqbal I, Iqbal K, Gong CX. Deficient brain insulin signaling
pathway in Alzheimer’s disease and diabetes. J Pathol. 2011; 225 (1): 54-62.
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Alfaro
JF, Gong CX, Monroe ME, Aldrich JT, Clauss TRW, Purvine SO, Wang Z, Camp II DG,
Shabanowitz J, Stanley P, Hart GW, Hunt DF, Yang F, Smith RD. Tandem mass
spectrometry identifies many mouse brain O-GlcNAcylated proteins including
targets of an EGF domain-specific O-GlcNAc transferase. Proc Natl Acad Sci USA.
2012; 109 (19): 7280-7285.
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Gong
CX, Liu F, Iqbal K. O-GlcNAc cycling modulates neurodegeneration. Proc Natl
Acad Sci U S A. 2012; 109 (43): 17319-20.
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Yang
Y, Ma D, Wang Y, Jiang T, Hu S, Zhang M, Yu X, Gong CX. Intranasal insulin
ameliorates tau hyperphosphorylation in a rat model of Type 2 Diabetes. J
Alzheimers Dis. 2013; 33: 329-338.
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Jin
N, Qian W, Yin X, Zhang L, Iqbal K, Grundke-Iqbal I, Gong CX, Liu F. CREB
regulates the expression of neuronal glucose transporter 3: a possible
mechanism related to impaired brain glucose uptake in Alzheimer's disease.
Nucleic Acids Res. 2013; 41: 3240-3256.
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Dai
CL, Shi J, Chen Y, Iqbal K, Liu F, Gong CX. Inhibition of protein synthesis
alters protein degradation through activation of protein kinase B (AKT). J Biol
Chem. 2013; 288 (33): 23875-83.
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Yang
Y, Zhang J, Ma D, Zhang M, Hu S, Shao S, Gong CX. Subcutaneous administration
of liraglutide ameliorates Alzheimer-associated tau hyperphosphorylation in
rats with Type 2 Diabetes. J Alzheimers Dis. 2013; 37: 637-648.
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Gong
CX, Alonso Adel C. Tau and beyond for Alzheimer's disease. J Alzheimers Dis.
2013; 37 (3): 465-466.
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Chen
Y, Liang Z, Tian Z, Blanchard J, Dai CL, Chalbot S, Iqbal K, Liu F, Gong CX.
Intracerebroventricular Streptozotocin Exacerbates Alzheimer-Like Changes of
3xTg-AD Mice. Mol Neurobiol. 2014; 49 (1): 547-62.
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Zhao
Y, Gu JH, Dai CL, Liu Q, Iqbal K, Liu F, Gong CX. Chronic cerebral
hypoperfusion causes decrease of O-GlcNAcylation, hyperphosphorylation of tau
and behavioral deficits in mice. Front Aging Neurosci. 2014; 6: 10.
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Chen
Y, Zhao Y, Dai CL, Liang Z, Run X, Iqbal K, Liu F, Gong CX: Intranasal insulin
restores insulin signaling, increases synaptic proteins, and reduces Aβ level
and microglia activation in the brains of 3xTg-AD mice. Exp Neurol 2014; 261:
610-619.
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Chen
Y, Run X, Liang Z, Zhao Y, Dai CL, Iqbal K, Liu F, Gong CX: Intranasal insulin
prevents anesthesia-induced hyperphosphorylation of tau in 3xTg-AD mice. Front
Aging Neurosci. 2014; 6: 100.
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Yuzwa
SA, Shan X, Jones BA, Zhao G, Woodward ML, Li X, Zhu Y, McEachern EJ, Silverman
MA, Watson NV, Gong CX, Vocadlo DJ. Pharmacological inhibition of O-GlcNAcase
(OGA) prevents cognitive decline and amyloid plaque formation in bigenic
tau/APP mutant mice. Mol Neurodegener 2014; 9: 42.
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Jin
N, Yin X, Yu D, Cao M, Gong CX, Iqbal K, Ding F, Gu X, Liu F. Truncation and
activation of GSK-3β by calpain I: a molecular mechanism links to tau
hyperphosphorylation in Alzheimer's disease. Sci Rep. 2015 Feb 2; 5: 8187.
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