H. N. Hafez, H. A. R. Hussein and A. B. A. El-Gazzar, “Synthesis of Substituted Thieno[2,3-d]pyrimidine-2,4-dithiones and Their S-Glycoside Analogues as Potential Antiviral and Antibacterial Agents,” European Journal of Medicinal Chemistry, Vol. 45, No. 9, 2010, pp. 4026-4034. http://dx.doi.org/10.1016/j.ejmech.2010.05.060

has been cited by the following article:

• TITLE: Novel Synthesis Approach and Antiplatelet Activity Evaluation of 6-Arylmethyleneamino-2-Alkylsulfonylpyrimidin-4(3H)-one Derivatives and Its Nucleosides

  AUTHORS: Abdulrahman G. Alshammari, Abdel-Rhman B. A. El-Gazzar

  KEYWORDS: Natural Asset; Financial Value; Neural Network

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.3 No.3A, November 6, 2013

  ABSTRACT: A new and efficient procedure has been designed for the preparation of 6-arylmethylene-amino-2-alkyl sulfonyl-pyrimidine. The first alkylthio group was introduced into the pyrimidine ring by S-alkylation. The introduction of the second one was successfully achieved using the phosphorous oxychloride method to afford 4-chloro-2-alkylthio-pyrimidines. Subsequent nucleophilic displacement by the corresponding alkylamines followed by glycoside bromide addition conveniently gave a series of the target compounds. Thus, the two same or different alkylamino groups were easily introduced into the pyrimidine ring through the two different approaches. The human anti-platelet aggregation activity of the newly synthesized compounds was also described.