J. N. Weinstein, T. G. Myers, P. M. Connor, S. H. Friend A. J. Fornace Jr., K. W. Kohn, T. Fojo, S. E. Bates, L. V. Rubinstein, N. L. Anderson, J. K. Buolamwini, W. W. van Osdol, A. P. Monks, D. A. Scudiero, E. A. Sausville, D. W. Zaharevitz, B. Bunow, V. N. Viswanadhan, G. S. Johnson, R. E. Wittes and K. D. Paull, “An InformationIntensive Approach to the Molecular Pharmacology of Cancer,” Science, Vol. 275, No. 5298, 1997, pp. 343-349.
http://dx.doi.org/10.1126/science.275.5298.343

has been cited by the following article:

• TITLE: Efficient Synthesis of a New Class of N-Nucleosides of 4H-Thiochromeno[2,3-d]pyrimidine-10-Sulfone as Potential Anticancer and Antibacterial Agents

  AUTHORS: Abdulrahman G. Alshammari, Abdel-Rhman B. A. El-Gazzar, Hend N. Hafez

  KEYWORDS: Thiochromene; Pyrimidine; Antibacterial; Anticancer Agents

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.3 No.3A, November 5, 2013

  ABSTRACT: A highly practical and efficient preparation of 6-methy-4H-thiochromene and 7-methyl-thiochromene[2,3-d]pyrimidine derivatives was developed via a multi-component reaction of 3-methyl-thiophenol (1), aldehydes (2), and malononitrile (3). A series of pyrimidine nucleoside, thiochromene[2,3-d]pyrimidine and thiochromene[2,3-d]pyrimidine-10-sulfone was efficiently obtained. These hybrid compounds were evaluated as potential antibacterial and anticancer agents and showed encouraging biological activities. Some of these derivatives showed broad-spectrum antitumour activity against the nine tumour subpanels tested, and demonstrated significant activity in the in vitro antitumour screening expressed by MG-MID log10GI50 value of －4.55, －4.67 and －4.73 of compounds 9a, 9b and 9c, respectively.