TITLE:
A New Process of Synthesizing Anandamide Derivatives from Arachidonic Acid in the Presence of Boron Catalyst
AUTHORS:
Mohammad Al-Masum, Linda Quinones
KEYWORDS:
Anandamide, Cross-Coupling, Microwave, Alcohol Amines
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.14 No.4,
December
23,
2024
ABSTRACT: Anandamide is part of the cannabinoid group and functions as a neurotransmitter. Anandamide plays a role in depression, pain, appetite, memory, and fertility. Since it is well documented that anandamide analog behaves as probes of the cannabinoid receptor, it is of great interest to find a new method of making new series of anandamide derivatives. Dennis Hall and his group recently reported a direct amidation process of carboxylic acid by ortho-iodo boronic acid. Using ortho-iodo boronic acid as a catalyst, we explore the amidation of arachidonic acid under microwave heating and synthesize anandamide derivatives in high yields.